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Kifc1 kinesin family member C1 [ Mus musculus (house mouse) ]

Gene ID: 100502766, updated on 3-Apr-2024

Summary

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Official Symbol
Kifc1provided by MGI
Official Full Name
kinesin family member C1provided by MGI
Primary source
MGI:MGI:109596
See related
Ensembl:ENSMUSG00000079553 AllianceGenome:MGI:109596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HSET; KNSL2; Gm4137; Kifc5a; Knsl2a; Tctex7; Tctex-7; Tctex7a; Tctex-7A; 100042970
Summary
Enables minus-end-directed microtubule motor activity. Acts upstream of or within minus-end-directed vesicle transport along microtubule and negative regulation of centrosome duplication. Located in endocytic vesicle; nucleus; and spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 30.2), liver E14.5 (RPKM 27.2) and 17 other tissues See more
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34094640..34109607, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33875664..33890633, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52316 Neighboring gene uncharacterized LOC118568329 Neighboring gene small integral membrane protein 40, pseudogene Neighboring gene microRNA 6967-2 Neighboring gene STARR-seq mESC enhancer starr_42414 Neighboring gene STARR-positive B cell enhancer ABC_E8918 Neighboring gene small integral membrane protein 40 Neighboring gene STARR-seq mESC enhancer starr_42418 Neighboring gene cDNA sequence BC051226

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kinesin-14 KIFC1 modulates spindle assembly and chromosome segregation in mouse spermatocytes. Wei YL, et al. Exp Cell Res, 2022 May 1. PMID 35259401
  2. Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis. Shan MM, et al. Development, 2022 Mar 1. PMID 35142352
  3. Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. Wang R, et al. BMC Cell Biol, 2008 Jan 31. PMID 18237440, Free PMC Article
  4. Identification of isoforms of a mitotic motor in mammalian spermatogenesis. Navolanic PM, et al. Biol Reprod, 2000 May. PMID 10775188
  5. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Kypri E, et al. Cell Mol Life Sci, 2014 Feb. PMID 23807208

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinesin-14 KIFC1 modulates spindle assembly and chromosome segregation in mouse spermatocytes.
    Title: Kinesin-14 KIFC1 modulates spindle assembly and chromosome segregation in mouse spermatocytes.
  2. Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis.
    Title: Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis.
  3. TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
    Title: TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
  4. Knockdown of KIFC5A dramatically reduces ciliogenesis.
    Title: The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5880, MGC67832, MGC117605

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables minus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within minus-end-directed vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vesicle transport along microtubule IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIFC1
Names
kinesin family c-terminal 5A
kinesin motor protein KIFC4
kinesin-like 2a
kinesin-related protein KIFC5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195298.1 → NP_001182227.1  kinesin-like protein KIFC1 isoform 1

    See identical proteins and their annotated locations for NP_001182227.1

    Status: VALIDATED

    Source sequence(s)
    AI322653, AI326799, AK133900, CX205646, CX209658
    Consensus CDS
    CCDS57065.1
    UniProtKB/Swiss-Prot
    O08671, O35230, Q497Y3, Q4A1N2, Q6PG90, Q8BV06, Q99L84, Q9JKZ0, Q9QWT9
    UniProtKB/TrEMBL
    A0A068BFR6
    Related
    ENSMUSP00000134572.2, ENSMUST00000173492.9
    Conserved Domains (4) summary
    smart00129
    Location:311 → 667
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:309 → 666
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam15233
    Location:171 → 300
    SYCE1; Synaptonemal complex central element protein 1
    pfam15619
    Location:146 → 306
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

  2. NM_001410585.1 → NP_001397514.1  kinesin-like protein KIFC1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT030732

  3. NM_001410586.1 → NP_001397515.1  kinesin-like protein KIFC1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT030732

  4. NM_001410587.1 → NP_001397516.1  kinesin-like protein KIFC1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT030732

  5. NM_001410588.1 → NP_001397517.1  kinesin-like protein KIFC1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT030732

RNA

  1. NR_177090.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT030732

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34094640..34109607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWT9.2 GenPept UniProtKB/Swiss-Prot:Q9QWT9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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