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USP2-AS1 USP2 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 100499227, updated on 23-Oct-2023

Summary

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Official Symbol
USP2-AS1provided by HGNC
Official Full Name
USP2 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:48673
See related
AllianceGenome:HGNC:48673
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gLINC; THY1-AS1
Expression
Biased expression in testis (RPKM 4.5), heart (RPKM 0.5) and 8 other tissues See more
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Genomic context

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See USP2-AS1 in Genome Data Viewer
Location:
11q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (119381778..119499233)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (119403309..119520748)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119252488..119369944)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3979 Neighboring gene C1q and TNF related 5 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:119228534-119229733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3980 Neighboring gene membrane frizzled-related protein Neighboring gene HNF4 motif-containing MPRA enhancer 223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119243670-119244170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119247037-119247615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119247932-119248520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119251478-119252467 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene major facilitator superfamily domain containing 14B pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119290361-119290928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119292628-119293194 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119293195-119293760 Neighboring gene Thy-1 cell surface antigen Neighboring gene double homeobox A pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119344129-119344629 Neighboring gene Sharpr-MPRA regulatory region 12960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119347323-119347824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119347825-119348324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119368781-119369640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3981 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:119381879-119382068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119404367-119404896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119417323-119418037 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119430656-119431156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119431157-119431657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5631 Neighboring gene uncharacterized LOC124902770 Neighboring gene uncharacterized LOC107984398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119456019-119456834 Neighboring gene keratin 8 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression. Tang J, et al. Cells, 2022 Oct 28. PMID 36359803, Free PMC Article
  2. Downregulation of lncRNA USP2‑AS1 in the placentas of pregnant women with non‑diabetic fetal macrosomia promotes trophoblast cell proliferation. Lu Y, et al. Mol Med Rep, 2022 Aug. PMID 35674181, Free PMC Article
  3. The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis. Zhu Y, et al. Mol Cell, 2022 Feb 3. PMID 35081364
  4. c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA. Li B, et al. Cell Death Dis, 2021 Oct 27. PMID 34707111, Free PMC Article
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
    Title: The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.
  2. Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression.
    Title: Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression.
  3. Downregulation of lncRNA USP2AS1 in the placentas of pregnant women with nondiabetic fetal macrosomia promotes trophoblast cell proliferation.
    Title: Downregulation of lncRNA USP2‑AS1 in the placentas of pregnant women with non‑diabetic fetal macrosomia promotes trophoblast cell proliferation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • USP2 antisense RNA 1 (head to head)
  • glycoLINC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_034160.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP003395, AP003396, BQ429648

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    119381778..119499233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    119403309..119520748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases