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Mob3c MOB kinase activator 3C [ Mus musculus (house mouse) ]

Gene ID: 100465, updated on 5-Mar-2024

Summary

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Official Symbol
Mob3cprovided by MGI
Official Full Name
MOB kinase activator 3Cprovided by MGI
Primary source
MGI:MGI:2140623
See related
Ensembl:ENSMUSG00000028709 AllianceGenome:MGI:2140623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mobkl2c; D130076I06Rik
Summary
Predicted to enable protein kinase activator activity. Predicted to be involved in positive regulation of protein phosphorylation and signal transduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB3C (MOB kinase activator 3C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 5.9), small intestine adult (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.06 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115675962..115693382)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115827886..115836185)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 14 Neighboring gene testis expressed 38 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene STARR-positive B cell enhancer ABC_E1650 Neighboring gene MAP kinase-interacting serine/threonine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6199 Neighboring gene kinocilin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MOB kinase activator 3C
Names
MOB1, Mps One Binder kinase activator-like 2C
mob1 homolog 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175308.5 → NP_780517.1  MOB kinase activator 3C

    See identical proteins and their annotated locations for NP_780517.1

    Status: VALIDATED

    Source sequence(s)
    AL626806, AL627085
    Consensus CDS
    CCDS18497.1
    UniProtKB/Swiss-Prot
    Q3UFI6, Q8BJG4
    UniProtKB/TrEMBL
    B1ASD4
    Related
    ENSMUSP00000030477.4, ENSMUST00000030477.4
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115675962..115693382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240381.2 → XP_011238683.1  MOB kinase activator 3C isoform X1

    See identical proteins and their annotated locations for XP_011238683.1

    UniProtKB/Swiss-Prot
    Q3UFI6, Q8BJG4
    UniProtKB/TrEMBL
    B1ASD4
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

  2. XM_011240382.3 → XP_011238684.1  MOB kinase activator 3C isoform X1

    See identical proteins and their annotated locations for XP_011238684.1

    UniProtKB/Swiss-Prot
    Q3UFI6, Q8BJG4
    UniProtKB/TrEMBL
    B1ASD4
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

  3. XM_036163554.1 → XP_036019447.1  MOB kinase activator 3C isoform X1

    UniProtKB/Swiss-Prot
    Q3UFI6, Q8BJG4
    UniProtKB/TrEMBL
    B1ASD4
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

RNA

  1. XR_004941793.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJG4.1 GenPept UniProtKB/Swiss-Prot:Q8BJG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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