MIR378B microRNA 378b [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR378Bprovided by HGNC
Official Full Name: microRNA 378bprovided by HGNC
Primary source: HGNC:HGNC:38283
See related: Ensembl:ENSG00000264534 miRBase:MI0014154; AllianceGenome:HGNC:38283
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 3p25.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (10330229..10330285)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (10323539..10323595)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (10371913..10371969)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated lncRNA Cyclin-dependent kinase inhibitor 2B antisense RNA 1 induces the proliferation and migration of colorectal cancer by miR-378b/CAPRIN2 axis.
Title: Upregulated lncRNA Cyclin-dependent kinase inhibitor 2B antisense RNA 1 induces the proliferation and migration of colorectal cancer by miR-378b/CAPRIN2 axis.
Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients.
Title: Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients.
miR378b represses the mRNA expression levels of COL1A1 via interference with SIRT6 in human dermal fibroblasts.
Title: MicroRNA‑378b regulates α‑1‑type 1 collagen expression via sirtuin 6 interference.
miR-378 regulates the angiogenic capacity of CD34(+) progenitor cells in STEMI patients.
Title: Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression.
Results indicate that miR-378 may serve as a tumor suppressor and play an important role in inhibiting glioma cell migration and invasion.
Title: Decreased expression of miR-378 correlates with tumor invasiveness and poor prognosis of patients with glioma.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

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General gene information

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Markers

D3S3990 (e-PCR)
- UniSTS:43011

G10673 (e-PCR)
- UniSTS:40748

SHGC-76702 (e-PCR)
- UniSTS:77698

D3S3903 (e-PCR)
- UniSTS:51858

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.