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Adh6b alcohol dehydrogenase 6B (class V) [ Mus musculus (house mouse) ]

Gene ID: 100417514, updated on 11-Apr-2024

Summary

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Official Symbol
Adh6bprovided by MGI
Official Full Name
alcohol dehydrogenase 6B (class V)provided by MGI
Primary source
MGI:MGI:2446626
See related
Ensembl:ENSMUSG00000074206 AllianceGenome:MGI:2446626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adh5b
Summary
Predicted to enable NAD-retinol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in ethanol oxidation; response to ethanol; and retinoid metabolic process. Predicted to be active in cytosol. Orthologous to human ADH6 (alcohol dehydrogenase 6 (class V)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
3 G3; 3 64.21 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138047176..138064621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138341412..138358859)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16559 Neighboring gene alcohol dehydrogenase 6A (class V) Neighboring gene predicted gene, 23467 Neighboring gene alcohol dehydrogenase 6 (class V), pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_09107 Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3. Szalai G, et al. Biochem Genet, 2008 Dec. PMID 18802746
  2. Merging protein, gene and genomic data: the evolution of the MDR-ADH family. Gonzàlez-Duarte R, et al. Heredity (Edinb), 2005 Sep. PMID 16121213
  3. Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes. Szalai G, et al. Eur J Biochem, 2002 Jan. PMID 11784316
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adh6b gene expression patterns.
    Title: Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alcohol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alcohol dehydrogenase 6B (class V)
NP_001357786.1
NP_001398420.1
NP_001398421.1
NP_001398422.1
XP_030108194.1
XP_036018689.1
XP_036018690.1
XP_036018691.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370857.2 → NP_001357786.1  alcohol dehydrogenase 6B (class V)

    Status: VALIDATED

    Source sequence(s)
    AC079845
    Consensus CDS
    CCDS89693.1
    UniProtKB/TrEMBL
    A0A1D5RMB0
    Related
    ENSMUSP00000148703.2, ENSMUST00000199673.6
    Conserved Domains (1) summary
    cl16912
    Location:10 → 382
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  2. NM_001411491.1 → NP_001398420.1  alcohol dehydrogenase 6B (class V)

    Status: VALIDATED

    Source sequence(s)
    AC079845
    UniProtKB/TrEMBL
    A0A1D5RMB0

  3. NM_001411492.1 → NP_001398421.1  alcohol dehydrogenase 6B (class V)

    Status: VALIDATED

    Source sequence(s)
    AC079845
    UniProtKB/TrEMBL
    A0A1D5RMB0

  4. NM_001411493.1 → NP_001398422.1  alcohol dehydrogenase 6B (class V)

    Status: VALIDATED

    Source sequence(s)
    AC079845
    UniProtKB/TrEMBL
    A0A1D5RMB0

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    138047176..138064621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162796.1 → XP_036018689.1  alcohol dehydrogenase 6B (class V) isoform X1

    UniProtKB/TrEMBL
    A0A1D5RMB0
    Conserved Domains (1) summary
    cl16912
    Location:10 → 382
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  2. XM_036162797.1 → XP_036018690.1  alcohol dehydrogenase 6B (class V) isoform X1

    UniProtKB/TrEMBL
    A0A1D5RMB0
    Conserved Domains (1) summary
    cl16912
    Location:10 → 382
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  3. XM_036162798.1 → XP_036018691.1  alcohol dehydrogenase 6B (class V) isoform X2

    Conserved Domains (1) summary
    cl16912
    Location:30 → 364
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

  4. XM_030252334.2 → XP_030108194.1  alcohol dehydrogenase 6B (class V) isoform X3

    Conserved Domains (1) summary
    cl16912
    Location:1 → 318
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_017403.2: Suppressed sequence

    Description
    NG_017403.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version

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