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Alkal2 ALK and LTK ligand 2 [ Mus musculus (house mouse) ]

Gene ID: 100294583, updated on 9-Dec-2024

Summary

Official Symbol
Alkal2provided by MGI
Official Full Name
ALK and LTK ligand 2provided by MGI
Primary source
MGI:MGI:3697448
See related
Ensembl:ENSMUSG00000054204 AllianceGenome:MGI:3697448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam150b; Augalpha; 6230419C23Rik
Summary
Predicted to enable protein tyrosine kinase activator activity and signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron projection development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human ALKAL2 (ALK and LTK ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in genital fat pad adult (RPKM 1.2), limb E14.5 (RPKM 0.8) and 23 other tissues See more
Orthologs
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Genomic context

See Alkal2 in Genome Data Viewer
Location:
12 A2; 12 13.0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30934323..30943855)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30884324..30893856)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11506 Neighboring gene transmembrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_31844 Neighboring gene predicted gene, 32320 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene acid phosphatase 1, soluble Neighboring gene Sh3 domain YSC-like 1 Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cellular_component  
is_active_in extracellular region  
is_active_in extracellular region  
located_in extracellular space  
is_active_in extracellular space  
located_in plasma membrane  

General protein information

Preferred Names
ALK and LTK ligand 2
Names
Augmentor alpha
Protein FAM150B
family with sequence similarity 150, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159743.2NP_001153215.1  ALK and LTK ligand 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001153215.1

    Status: VALIDATED

    Source sequence(s)
    AC160932
    Consensus CDS
    CCDS49044.1
    UniProtKB/Swiss-Prot
    G3X9F3, Q80UG6
    Related
    ENSMUSP00000070037.7, ENSMUST00000067087.7
    Conserved Domains (1) summary
    pfam15129
    Location:32150
    FAM150; FAM150 family
  2. NM_001377064.1NP_001363993.1  ALK and LTK ligand 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC160932
    Conserved Domains (1) summary
    pfam15129
    Location:32132
    FAM150; FAM150 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    30934323..30943855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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