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ZNF587B zinc finger protein 587B [ Homo sapiens (human) ]

Gene ID: 100293516, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF587Bprovided by HGNC
Official Full Name
zinc finger protein 587Bprovided by HGNC
Primary source
HGNC:HGNC:37142
See related
Ensembl:ENSG00000269343 AllianceGenome:HGNC:37142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 3.0), skin (RPKM 2.7) and 25 other tissues See more
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Genomic context

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See ZNF587B in Genome Data Viewer
Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57830299..57846238)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60927216..60943143)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58341667..58357606)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58322897-58323548 Neighboring gene zinc finger protein 552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58333533-58334033 Neighboring gene FKBP prolyl isomerase 1A pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15167 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:58361669-58362868 Neighboring gene uncharacterized LOC124904782 Neighboring gene zinc finger protein 587 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Computer sequence analysis of human highly conserved zinc finger modules. Petroni D, et al. DNA Seq, 1998. PMID 10520746
  2. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article
  3. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: ZNF587

Homology

Clone Names

  • FLJ16599, FLJ52732, FLJ52828

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 587B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204818.2 → NP_001191747.1  zinc finger protein 587B isoform 2

    See identical proteins and their annotated locations for NP_001191747.1

    Status: VALIDATED

    Source sequence(s)
    AC010522, AK299091, CA427231, DB065500
    Consensus CDS
    CCDS56109.1
    UniProtKB/Swiss-Prot
    B4DR41, E7ETH6
    Related
    ENSP00000392410.2, ENST00000442832.8
    Conserved Domains (5) summary
    smart00349
    Location:15 → 56
    KRAB; krueppel associated box
    COG5048
    Location:163 → 372
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 54
    KRAB; KRAB box
    pfam13465
    Location:340 → 365
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001376223.1 → NP_001363152.1  zinc finger protein 587B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010522
    Consensus CDS
    CCDS92699.1
    UniProtKB/TrEMBL
    M0QY62
    Related
    ENSP00000469623.1, ENST00000594901.2
    Conserved Domains (4) summary
    COG5048
    Location:215 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:552 → 572
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:15 → 55
    KRAB; KRAB box
    pfam13465
    Location:564 → 588
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57830299..57846238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60927216..60943143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7ETH6.1 GenPept UniProtKB/Swiss-Prot:E7ETH6

Gene LinkOut

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