U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RASA4B RAS p21 protein activator 4B [ Homo sapiens (human) ]

Gene ID: 100271927, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
RASA4Bprovided by HGNC
Official Full Name
RAS p21 protein activator 4Bprovided by HGNC
Primary source
HGNC:HGNC:35202
See related
Ensembl:ENSG00000170667 AllianceGenome:HGNC:35202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 22.0), brain (RPKM 17.5) and 24 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RASA4B in Genome Data Viewer
Location:
7q22.1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102479976..102517777, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103797581..103835325, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102120423..102158224, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467 Neighboring gene RNA polymerase II subunit J Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102131046-102131546 Neighboring gene uncharacterized LOC124901715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102151767-102152268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102152269-102152768 Neighboring gene Sharpr-MPRA regulatory region 3260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102156842-102157466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165421-102165922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165923-102166422 Neighboring gene POLR2J3-UPK3BL2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102179485-102180312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102184221-102184721 Neighboring gene uroplakin 3B like 2 Neighboring gene speedy/RINGO cell cycle regulator family member E2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Lockyer PJ, et al. Curr Biol, 2001 Jun 26. PMID 11448776
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  3. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  4. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074
  5. TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing. Demirdizen E, et al. Neuro Oncol, 2023 Jun 2. PMID 36215168, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ50902

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ras GTPase-activating protein 4B
Names
putative Ras GTPase-activating protein 4B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277335.2 → NP_001264264.1  ras GTPase-activating protein 4B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093668
    Consensus CDS
    CCDS59506.1
    UniProtKB/TrEMBL
    F5GXT2, Q2NL74
    Related
    ENSP00000440982.1, ENST00000541662.5
    Conserved Domains (5) summary
    cd04025
    Location:134 → 257
    C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
    cd04054
    Location:6 → 126
    C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
    cd05395
    Location:265 → 550
    RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
    smart00323
    Location:244 → 605
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cl17171
    Location:542 → 635
    PH-like; Pleckstrin homology-like domain

  2. NM_001367767.2 → NP_001354696.1  ras GTPase-activating protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093668
    Consensus CDS
    CCDS94160.1
    UniProtKB/Swiss-Prot
    C9J798
    UniProtKB/TrEMBL
    Q2NL74
    Related
    ENSP00000417895.1, ENST00000465829.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102479976..102517777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419681.1 → XP_047275637.1  ras GTPase-activating protein 4B isoform X1

    UniProtKB/TrEMBL
    F8W6L0
    Related
    ENSP00000303968.6, ENST00000306682.6

  2. XM_047419684.1 → XP_047275640.1  ras GTPase-activating protein 4B isoform X3

  3. XM_047419685.1 → XP_047275641.1  ras GTPase-activating protein 4B isoform X3

  4. XM_047419686.1 → XP_047275642.1  ras GTPase-activating protein 4B isoform X4

  5. XM_047419682.1 → XP_047275638.1  ras GTPase-activating protein 4B isoform X2

    UniProtKB/TrEMBL
    A0A9L9PXW0
    Related
    ENSP00000516751.1, ENST00000707123.1

  6. XM_047419683.1 → XP_047275639.1  ras GTPase-activating protein 4B isoform X5

RNA

  1. XR_007059979.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103797581..103835325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356945.1 → XP_054212920.1  ras GTPase-activating protein 4B isoform X1

  2. XM_054356947.1 → XP_054212922.1  ras GTPase-activating protein 4B isoform X3

  3. XM_054356948.1 → XP_054212923.1  ras GTPase-activating protein 4B isoform X3

  4. XM_054356950.1 → XP_054212925.1  ras GTPase-activating protein 4B isoform X4

  5. XM_054356944.1 → XP_054212919.1  ras GTPase-activating protein 4B isoform X6

  6. XM_054356946.1 → XP_054212921.1  ras GTPase-activating protein 4B isoform X2

  7. XM_054356949.1 → XP_054212924.1  ras GTPase-activating protein 4B isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C9J798.2 GenPept UniProtKB/Swiss-Prot:C9J798

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous