U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARHGEF33 Rho guanine nucleotide exchange factor 33 [ Homo sapiens (human) ]

Gene ID: 100271715, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ARHGEF33provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 33provided by HGNC
Primary source
HGNC:HGNC:37252
See related
Ensembl:ENSG00000214694 AllianceGenome:HGNC:37252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.6), brain (RPKM 0.5) and 12 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ARHGEF33 in Genome Data Viewer
Location:
2p22.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38889875..38975454)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (38898364..38983970)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39117016..39202595)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:39102285-39103268 Neighboring gene RNA, U6 small nuclear 851, pseudogene Neighboring gene MORN repeat containing 2 Neighboring gene uncharacterized LOC105374471 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:39170060-39171010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:39174178-39174678 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:39174679-39175179 Neighboring gene RNA, 7SL, cytoplasmic 96, pseudogene Neighboring gene uncharacterized LOC375196 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene MPRA-validated peak3669 silencer Neighboring gene RNA, U6 small nuclear 198, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11383 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 13

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer. Ishaque N, et al. Nat Commun, 2018 Nov 14. PMID 30429477, Free PMC Article
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  4. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: MORN2

Homology

Clone Names

  • FLJ41381

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rho guanine nucleotide exchange factor 33
Names
DH and coiled-coil domain-containing protein ENSP00000381780
Rho guanine nucleotide exchange factor (GEF) 33

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145451.5 → NP_001138923.2  rho guanine nucleotide exchange factor 33 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC018693, AC019171
    Consensus CDS
    CCDS46263.2
    UniProtKB/TrEMBL
    A0A8V8TLC5
    Related
    ENSP00000387020.1, ENST00000409978.7
    Conserved Domains (1) summary
    cl02571
    Location:269 → 445
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  2. NM_001367623.3 → NP_001354552.1  rho guanine nucleotide exchange factor 33 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC018693, AC019171
    UniProtKB/Swiss-Prot
    A8MVX0, J3KPX2
    UniProtKB/TrEMBL
    A0A8V8TLC5
    Conserved Domains (3) summary
    COG1196
    Location:21 → 127
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12323
    Location:463 → 688
    PRK12323; DNA polymerase III subunit gamma/tau
    cl02571
    Location:269 → 436
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    38889875..38975454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    38898364..38983970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MVX0.2 GenPept UniProtKB/Swiss-Prot:A8MVX0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous