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MED16 mediator complex subunit 16 [ Homo sapiens (human) ]

Gene ID: 10025, updated on 5-Mar-2024

Summary

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Official Symbol
MED16provided by HGNC
Official Full Name
mediator complex subunit 16provided by HGNC
Primary source
HGNC:HGNC:17556
See related
Ensembl:ENSG00000175221 MIM:604062; AllianceGenome:HGNC:17556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRIP92; THRAP5; TRAP95
Summary
Enables thyroid hormone receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation from RNA polymerase II promoter. Located in membrane. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 10.5), kidney (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (867963..893187, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (824038..855915, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (867963..893187, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene elastase, neutrophil expressed Neighboring gene complement factor D Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:871223-871802 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:885344-885844 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:885845-886345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13573 Neighboring gene RNA, U6 small nuclear 9 Neighboring gene MPRA-validated peak3217 silencer Neighboring gene R3H domain containing 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:904059-904817 Neighboring gene Sharpr-MPRA regulatory region 9324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance. Gao H, et al. J Biol Chem, 2020 Jul 31. PMID 32532820, Free PMC Article
  2. Homozygous MED25 mutation implicated in eye-intellectual disability syndrome. Basel-Vanagaite L, et al. Hum Genet, 2015 Jun. PMID 25792360
  3. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Wallberg AE, et al. Mol Cell, 2003 Nov. PMID 14636573
  4. TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Malik S, et al. Mol Cell Biol, 2002 Aug. PMID 12101254, Free PMC Article
  5. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Fondell JD, et al. Proc Natl Acad Sci U S A, 1996 Aug 6. PMID 8710870, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-beta signaling and radioiodine resistance.
    Title: Mediator complex subunit 16 is down-regulated in papillary thyroid cancer, leading to increased transforming growth factor-β signaling and radioiodine resistance.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear vitamin D receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 16
Names
thyroid hormone receptor-associated protein 5
thyroid hormone receptor-associated protein complex 95 kDa component
thyroid hormone receptor-associated protein, 95-kD subunit
vitamin D3 receptor-interacting protein complex 92 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005481.3 → NP_005472.2  mediator of RNA polymerase II transcription subunit 16

    See identical proteins and their annotated locations for NP_005472.2

    Status: VALIDATED

    Source sequence(s)
    AL137732, BC017282, BI461485, BQ015734, CB050542
    Consensus CDS
    CCDS12047.1
    UniProtKB/Swiss-Prot
    Q6PJT2, Q96AD4, Q96I35, Q9Y2X0, Q9Y652
    Related
    ENSP00000325612.1, ENST00000325464.6
    Conserved Domains (3) summary
    smart00320
    Location:70 → 109
    WD40; WD40 repeats
    sd00039
    Location:85 → 116
    7WD40; WD40 repeat [structural motif]
    pfam11635
    Location:119 → 828
    Med16; Mediator complex subunit 16

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    867963..893187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026120.3 → XP_016881609.1  mediator of RNA polymerase II transcription subunit 16 isoform X1

  2. XM_047438010.1 → XP_047293966.1  mediator of RNA polymerase II transcription subunit 16 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187622.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    47189..60469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    824038..855915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319463.1 → XP_054175438.1  mediator of RNA polymerase II transcription subunit 16 isoform X2

  2. XM_054319462.1 → XP_054175437.1  mediator of RNA polymerase II transcription subunit 16 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2X0.2 GenPept UniProtKB/Swiss-Prot:Q9Y2X0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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