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MRPL23-AS1 MRPL23 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 100133545, updated on 8-Nov-2023

Summary

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Official Symbol
MRPL23-AS1provided by HGNC
Official Full Name
MRPL23 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:42812
See related
Ensembl:ENSG00000226416 AllianceGenome:HGNC:42812
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TP53LC10
Expression
Ubiquitous expression in endometrium (RPKM 1.1), skin (RPKM 1.1) and 24 other tissues See more
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Genomic context

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See MRPL23-AS1 in Genome Data Viewer
Location:
11p15.5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1983209..1989920, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (2070866..2077587, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2004439..2011150, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene troponin T3, fast skeletal type Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1956346-1956534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1956988-1957585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1970491-1971228 Neighboring gene small nucleolar RNA, C/D box 131 Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1979269-1980047 Neighboring gene VISTA enhancer hs1488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2003101-2003870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2004639-2005408 Neighboring gene H19/IGF2 enhancer region Neighboring gene long intergenic non-protein coding RNA 1219 Neighboring gene microRNA 675 Neighboring gene H19 imprinted maternally expressed transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long Noncoding RNA MRPL23-AS1 Promotes Adenoid Cystic Carcinoma Lung Metastasis. Chen CW, et al. Cancer Res, 2020 Jun 1. PMID 32098781
  2. Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/β-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9). Zhang H, et al. Bioengineered, 2021 Dec. PMID 33356805, Free PMC Article
  3. TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation. Xu W, et al. Genome Res, 2022 Jun. PMID 35609991, Free PMC Article
  4. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/beta-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).
    Title: Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/β-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).
  2. Long Noncoding RNA MRPL23-AS1 Promoteoid Cystic Carcinoma Lung Metastasis.
    Title: Long Noncoding RNA MRPL23-AS1 Promotes Adenoid Cystic Carcinoma Lung Metastasis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • MRPL23 antisense RNA 1 (non-protein coding)

Clone Names

  • AC051649.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024471.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC051649
    Related
    ENST00000419080.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1983209..1989920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160004.1 Reference GRCh38.p14 PATCHES

    Range
    175731..182442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    2070866..2077587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases