U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FILNC1 FOXO induced long non-coding RNA 1 [ Homo sapiens (human) ]

Gene ID: 100132735, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Official Symbol
FILNC1provided by HGNC
Official Full Name
FOXO induced long non-coding RNA 1provided by HGNC
Primary source
HGNC:HGNC:53755
See related
Ensembl:ENSG00000231426 AllianceGenome:HGNC:53755
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene produces a long non-coding RNA that is induced by forkhead box O proteins and plays a role in stress-induced apoptosis. Knock down of transcripts at this locus results in increased renal tumor growth and alteration in genes involved in glucose metabolism. This RNA interacts with heterogeneous nuclear ribonucleoprotein D and prevents it from binding to Myc mRNA, therefore suppressing Myc activity. Alternative splicing and transcriptional start site usage results in multiple transcript variants. [provided by RefSeq, Oct 2017]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See FILNC1 in Genome Data Viewer
Location:
6q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (139771073..139860471)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (140954833..141044210)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (140092210..140181608)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr6.4971 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:139961222-139961389 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17613 Neighboring gene CRISPRi-validated cis-regulatory element chr6.4973 Neighboring gene thyroid hormone receptor interactor 4 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr6:140091503-140091680 Neighboring gene NANOG hESC enhancer GRCh37_chr6:140205336-140205876 Neighboring gene VISTA enhancer hs1644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25173 Neighboring gene Sharpr-MPRA regulatory region 3903 Neighboring gene uncharacterized LOC103352541 Neighboring gene Sharpr-MPRA regulatory region 1100 Neighboring gene long intergenic non-protein coding RNA 2941 Neighboring gene uncharacterized LOC107986652

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Xiao ZD, et al. Nat Commun, 2017 Oct 4. PMID 28978906, Free PMC Article
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. Lauc G, et al. PLoS Genet, 2013. PMID 23382691, Free PMC Article
  3. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
  4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Markers

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_038399.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL050338, BM905115
    Related
    ENST00000647420.1

  2. NR_138541.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL050338, BM788274

  3. NR_138542.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA058905, AL050338, BM788274

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    139771073..139860471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    140954833..141044210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials