AHI1-DT AHI1 divergent transcript [Homo sapiens (human)] - Gene

Summary

Official Symbol: AHI1-DTprovided by HGNC
Official Full Name: AHI1 divergent transcriptprovided by HGNC
Primary source: HGNC:HGNC:32526
See related: Ensembl:ENSG00000231028 AllianceGenome:HGNC:32526
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C6orf217; LINC00271; NCRNA00271
Expression: Biased expression in thyroid (RPKM 1.3), kidney (RPKM 1.1) and 11 other tissues See more
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Genomic context

Location:: 6q23.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (135497801..135716055)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (136686055..136904326)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (135818939..136037193)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LINC00271 is downregulated in adrenocortical carcinoma (ACC) and associated with prognosis - patients with low LINC00271 expression survived a shorter time than patients with high expression. Low LINC00271 expression was positively associated with WNT signaling, cell cycle, and chromosome segregation pathways commonly dysregulated in ACC. Results suggest that LINC00271 may be a prognostic marker in ACC.
Title: Adrenocortical tumors have a distinct, long, non-coding RNA expression profile and LINC00271 is downregulated in malignancy.
Results show that LINC00271 expression was significantly downregulated in papillary thyroid cancer (PTC) and suggest that LINC00271 is a possible suppressor gene in PTC.
Title: Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer.
There was no significant difference in brain expression of C6orf217 between patients and controls and no genotypic effect.
Title: Lymphoblast and brain expression of AHI1 and the novel primate-specific gene, C6orf217, in schizophrenia and bipolar disorder.
Observational study of gene-disease association. (HuGE Navigator)
Title: Replication of recently described type 2 diabetes gene variants in a South Indian population.
Genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

AL021857 (e-PCR)
- UniSTS:22343

RH121322 (e-PCR)
- UniSTS:138586

RH120250 (e-PCR)
- UniSTS:132706

G01852 (e-PCR)
- UniSTS:10101

AL021856 (e-PCR)
- UniSTS:14825

Other Names

long intergenic non-protein coding RNA 271

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.