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ARMCX4 armadillo repeat containing X-linked 4 [ Homo sapiens (human) ]

Gene ID: 100131755, updated on 8-Mar-2024

Summary

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Official Symbol
ARMCX4provided by HGNC
Official Full Name
armadillo repeat containing X-linked 4provided by HGNC
Primary source
HGNC:HGNC:28615
See related
Ensembl:ENSG00000196440 MIM:301046; AllianceGenome:HGNC:28615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASP4; CXorf35
Summary
The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in ovary (RPKM 3.6), brain (RPKM 2.9) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
Xq22.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101418278..101535988)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99862393..99980621)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100673266..100790975)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RPL36A-HNRNPH2 readthrough Neighboring gene heterogeneous nuclear ribonucleoprotein H2 Neighboring gene galactosidase alpha Neighboring gene peptidylprolyl isomerase A pseudogene 90 Neighboring gene PRKCI pseudogene 1 Neighboring gene armadillo repeat containing X-linked 1 Neighboring gene armadillo repeat containing X-linked 7, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The armadillo family of structural proteins. Hatzfeld M. Int Rev Cytol, 1999. PMID 9770300
  2. A repeating amino acid motif shared by proteins with diverse cellular roles. Peifer M, et al. Cell, 1994 Mar 11. PMID 7907279
  3. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
  4. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
  5. The full-ORF clone resource of the German cDNA Consortium. Bechtel S, et al. BMC Genomics, 2007 Oct 31. PMID 17974005, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: ARMCX1

Homology

Clone Names

  • FLJ39636, FLJ43051, FLJ45041, MGC40053, DKFZp586N0819, DKFZp781M0415

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
armadillo repeat-containing X-linked protein 4
Names
armadillo repeat containing, X-linked 4 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017196.3 RefSeqGene

    Range
    72179..82530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256155.3 → NP_001243084.2  armadillo repeat-containing X-linked protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a protein-coding variant and contains a long, terminal coding exon instead of extensive splicing found in variant 2. The full extent of the 5' UTR has not been determined.
    Source sequence(s)
    KF459252, Z68873
    Consensus CDS
    CCDS59170.1
    UniProtKB/Swiss-Prot
    A8K928, B3KXA4, F8W8Y7, Q5H9K8, Q5H9R4, Q8N8D6
    Related
    ENSP00000404304.3, ENST00000423738.5
    Conserved Domains (3) summary
    PRK07735
    Location:84 → 320
    PRK07735; NADH-quinone oxidoreductase subunit C
    pfam04826
    Location:2032 → 2283
    Arm_2; Armadillo-like
    pfam06682
    Location:1514 → 1646
    SARAF; SOCE-associated regulatory factor of calcium homoeostasis

RNA

  1. NR_028407.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC234775, AL035422, Z68873

  2. NR_045861.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC234775, Z68873

  3. NR_045862.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC234775, Z68873

  4. NR_045863.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    Z68873
    Related
    ENST00000445416.5

  5. NR_045864.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC234775, Z68873

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    101418278..101535988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    99862393..99980621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152583.2: Suppressed sequence

    Description
    NM_152583.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5H9R4.3 GenPept UniProtKB/Swiss-Prot:Q5H9R4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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