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LRRC70 leucine rich repeat containing 70 [ Homo sapiens (human) ]

Gene ID: 100130733, updated on 16-Mar-2024

Summary

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Official Symbol
LRRC70provided by HGNC
Official Full Name
leucine rich repeat containing 70provided by HGNC
Primary source
HGNC:HGNC:35155
See related
Ensembl:ENSG00000186105 AllianceGenome:HGNC:35155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLRN
Summary
Involved in positive regulation of response to cytokine stimulus. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 4.2), thyroid (RPKM 3.6) and 22 other tissues See more
Orthologs
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Genomic context

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Location:
5q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (62578819..62581446)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (63398458..63401085)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61874646..61877273)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene importin 11 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61864515-61865147 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:61865148-61865779 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene IPO11-LRRC70 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr5:61905853-61905971 Neighboring gene ribosomal protein L35a pseudogene 14 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:62013981-62014721 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:62265821-62266321 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62277957-62278458 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:62278459-62278958 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:62421058-62421608 Neighboring gene MPRA-validated peak5264 silencer Neighboring gene dedicator of cytokinesis 9 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses. Wang W, et al. Biochem Biophys Res Commun, 2003 Jun 13. PMID 12767927
  2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  3. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine and growth factor responses.
    Title: Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responses.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough IPO11-LRRC70

Readthrough gene: IPO11-LRRC70, Included gene: IPO11

Homology

Clone Names

  • FLJ41026, DKFZp686E10165

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat-containing protein 70
Names
synleurin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181506.5 → NP_852607.3  leucine-rich repeat-containing protein 70 precursor

    See identical proteins and their annotated locations for NP_852607.3

    Status: VALIDATED

    Source sequence(s)
    AK123022, BC110838
    Consensus CDS
    CCDS47218.1
    UniProtKB/Swiss-Prot
    Q6ZWI5, Q7Z2Q7
    Related
    ENSP00000399441.1, ENST00000334994.6
    Conserved Domains (5) summary
    smart00013
    Location:31 → 62
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:359 → 398
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:159 → 340
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:110 → 133
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:133 → 192
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    62578819..62581446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    63398458..63401085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_009724.1: Suppressed sequence

    Description
    NG_009724.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z2Q7.1 GenPept UniProtKB/Swiss-Prot:Q7Z2Q7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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