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LEISA1 lncRNA enhancing IL-6/STAT3 signaling activation 1 [ Homo sapiens (human) ]

Gene ID: 100126784, updated on 10-Oct-2023

Summary

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Official Symbol
LEISA1provided by HGNC
Official Full Name
lncRNA enhancing IL-6/STAT3 signaling activation 1provided by HGNC
Primary source
HGNC:HGNC:55264
See related
AllianceGenome:HGNC:55264
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEISA; NAV2-AS6
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Genomic context

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Location:
11p15.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (19710934..19714672, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19831387..19835125, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19732480..19736218, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene neuron navigator 2 Neighboring gene small nucleolar RNA SNORA1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19823 Neighboring gene microRNA 4486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4523 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:19691725-19692246 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19830 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:19719279-19719442 Neighboring gene NANOG hESC enhancer GRCh37_chr11:19722632-19723146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:19724554-19725054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:19725055-19725555 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:19734258-19734451 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:19768963-19769464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:19778561-19779113 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:19793703-19794210 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:19794211-19794719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3201 Neighboring gene microRNA 4694 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:19842672-19843172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:19843173-19843673 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:19913575-19914774 Neighboring gene Sharpr-MPRA regulatory region 6685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4524 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:20000027-20001226 Neighboring gene NAV2 antisense RNA 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA LEISA promotes progression of lung adenocarcinoma via enhancing interaction between STAT3 and IL-6 promoter. Wu S, et al. Oncogene, 2021 May. PMID 33859372
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • NAV2 antisense RNA 6
  • lncRNA enhancing IL-6/STAT3 signaling activation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_015384.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009549, BC035903, BC047636, BF439944, DA492854, H83398

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    19710934..19714672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    19831387..19835125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases