VTRNA2-1 vault RNA 2-1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: VTRNA2-1provided by HGNC
Official Full Name: vault RNA 2-1provided by HGNC
Primary source: HGNC:HGNC:37054
See related: Ensembl:ENSG00000270123 MIM:614938; AllianceGenome:HGNC:37054
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CBL3; CBL-3; hvg-5; nc886; MIR886; VTRNA2; MIRN886; svtRNA2-1a; hsa-mir-886; pre-miR-886
Summary: This gene produces an RNA polymerase III transcript that resembles both a component of the ribonucleoprotein vault particle and a pre-microRNA. However, the RNA product does not function as a vault or microRNA; rather, it acts as a direct inhibitor of protein kinase R (also known as eukaryotic translation initiation factor 2-alpha kinase 2, EIF2AK2), and thereby plays an important role in the regulation of cell growth. This gene is located in the vicinity of a differentially methylated region (DMR) and is imprinted and may show allele-specific expression. This gene is also often hypermethylated and repressed in cancers. [provided by RefSeq, Nov 2015]
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Genomic context

Location:: 5q31.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (136080491..136080598, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (136603010..136603117, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (135416180..135416287, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

nc886, an RNA Polymerase III-Transcribed Noncoding RNA Whose Expression Is Dynamic and Regulated by Intriguing Mechanisms.
Title: nc886, an RNA Polymerase III-Transcribed Noncoding RNA Whose Expression Is Dynamic and Regulated by Intriguing Mechanisms.
Small noncoding vault RNA2-1 disrupts gut epithelial barrier function via interaction with HuR.
Title: Small noncoding vault RNA2-1 disrupts gut epithelial barrier function via interaction with HuR.
MicroRNA-886 suppresses osteosarcoma cell proliferation and its maturation is suppressed by long non-coding RNA OXCT1-AS1.
Title: MicroRNA-886 suppresses osteosarcoma cell proliferation and its maturation is suppressed by long non-coding RNA OXCT1-AS1.
Suppression of miR-886-3p mediated by arecoline (ARE) contributes to the progression of oral squamous cell carcinoma.
Title: Suppression of miR-886-3p mediated by arecoline (ARE) contributes to the progression of oral squamous cell carcinoma.
nc886, a Non-Coding RNA, Is a New Biomarker and Epigenetic Mediator of Cellular Senescence in Fibroblasts.
Title: nc886, a Non-Coding RNA, Is a New Biomarker and Epigenetic Mediator of Cellular Senescence in Fibroblasts.
Upregulation of miR-886 indicates poor prognosis and promotes tumour progression of prostate cancer.
Title: Upregulation of miR-886 indicates poor prognosis and promotes tumour progression of prostate cancer.
Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth.
Title: Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth.
VTRNA2-1: Genetic Variation, Heritable Methylation and Disease Association.
Title: VTRNA2-1: Genetic Variation, Heritable Methylation and Disease Association.
Nc886, a Novel Suppressor of the Type I Interferon Response Upon Pathogen Intrusion.
Title: Nc886, a Novel Suppressor of the Type I Interferon Response Upon Pathogen Intrusion.
Differential hypermethylation of the VTRNA2-1 promoter in hepatocellular carcinoma as a prognostic factor: Tumor marker prognostic study.
Title: Differential hypermethylation of the VTRNA2-1 promoter in hepatocellular carcinoma as a prognostic factor: Tumor marker prognostic study.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

cord blood lymphocyte-derived noncoding RNA 3
microRNA 886
noncoding RNA 886

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.