U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Krt83 keratin 83 [ Mus musculus (house mouse) ]

Gene ID: 100126226, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Krt83provided by MGI
Official Full Name
keratin 83provided by MGI
Primary source
MGI:MGI:3690448
See related
Ensembl:ENSMUSG00000067613 AllianceGenome:MGI:3690448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430421N21Rik
Summary
Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to human KRT81 (keratin 81) and KRT83 (keratin 83). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 3.0), ovary adult (RPKM 0.7) and 3 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15 F2; 15 56.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101383011..101389393, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101485130..101491512, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 81 Neighboring gene keratin 86 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316581-101316768 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:101316810-101316963 Neighboring gene STARR-seq mESC enhancer starr_39797 Neighboring gene STARR-seq mESC enhancer starr_39798 Neighboring gene type II keratin Kb32P Neighboring gene predicted gene, 53914 Neighboring gene keratin 85

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins. Yu DW, et al. J Invest Dermatol, 1991 Aug. PMID 1712823
  2. Structure and site of expression of a murine type II hair keratin. Tobiasch E, et al. Mol Biol Rep, 1992 Feb. PMID 1372089
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
type II hair keratin
Names
keratin type II

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201323.1 → NP_001188252.1  type II hair keratin

    Status: VALIDATED

    Source sequence(s)
    AI561926, AK133718
    Consensus CDS
    CCDS49735.1
    UniProtKB/TrEMBL
    E9Q1Y9, Q61726
    Related
    ENSMUSP00000023718.8, ENSMUST00000023718.9
    Conserved Domains (3) summary
    pfam00038
    Location:103 → 414
    Filament; Intermediate filament protein
    pfam16208
    Location:38 → 100
    Keratin_2_head; Keratin type II head
    cl23720
    Location:313 → 381
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101383011..101389393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous