SRA1 steroid receptor RNA activator 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRA1provided by HGNC
Official Full Name: steroid receptor RNA activator 1provided by HGNC
Primary source: HGNC:HGNC:11281
See related: Ensembl:ENSG00000213523 MIM:603819; AllianceGenome:HGNC:11281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SRA; SRAP; STRAA1; pp7684
Summary: Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
Expression: Ubiquitous expression in adrenal (RPKM 15.0), testis (RPKM 12.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (140550067..140558093, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (141075497..141083524, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (139929652..139937678, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy.
Title: Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy.
Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.
Title: Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.
Steroid Receptor Coactivator-1 (SRC-1) Promoted Cell Metastasis of Gastric Cancer via VEGFC Activator by NF-kappaB.
Title: Steroid Receptor Coactivator-1 (SRC-1) Promoted Cell Metastasis of Gastric Cancer via VEGFC Activator by NF-κB.
Ratios of peripheral blood mononuclear cells to lncRNA steroid receptor RNA activator as new indicators of metabolic syndrome.
Title: Ratios of peripheral blood mononuclear cells to lncRNA steroid receptor RNA activator as new indicators of metabolic syndrome.
Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
Title: Positive association between SRA1 rs801460 variant and proliferative type of benign breast disease with atypia in Ukrainian females.
LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition.
Title: LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition.
Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation.
Title: Adipose Tissue Steroid Receptor RNA Activator 1 (SRA1) Expression Is Associated with Obesity, Insulin Resistance, and Inflammation.
Steroid receptor RNA activator gene footprint in the progression and drug resistance of colorectal cancer through oxidative phosphorylation pathway.
Title: Steroid receptor RNA activator gene footprint in the progression and drug resistance of colorectal cancer through oxidative phosphorylation pathway.
Long, Noncoding RNA SRA Induces Apoptosis of beta-Cells by Promoting the IRAK1/LDHA/Lactate Pathway.
Title: Long, Noncoding RNA SRA Induces Apoptosis of β-Cells by Promoting the IRAK1/LDHA/Lactate Pathway.
Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.
Title: Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hypogonadotropic hypogonadism 7 with or without anosmia MedGen: C0342384 OMIM: 146110 GeneReviews: Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC170950P4 (e-PCR)
- UniSTS:271622

RH45891 (e-PCR)
- UniSTS:52536

D5S2251E (e-PCR)
- UniSTS:154457

D5S2258E (e-PCR)
- UniSTS:154464

RH16024 (e-PCR)
- UniSTS:48996

SHGC-56860 (e-PCR)
- UniSTS:27791

SHGC-132909 (e-PCR)
- UniSTS:173979

A007D18 (e-PCR)
- UniSTS:46507

RH122995 (e-PCR)
- UniSTS:135387

SGC30750 (e-PCR)
- UniSTS:12023

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables steroid receptor RNA activator RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid receptor RNA activator RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estrogen stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
NOT part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: steroid receptor RNA activator 1

Names: steroid receptor RNA activator 1 (complexes with NCOA1); steroid receptor RNA activator protein; steroid receptor coactivator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031847.1 RefSeqGene

Range

5621..13026

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001035235.4 → NP_001030312.3 steroid receptor RNA activator 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC011399, BC040043

Consensus CDS

CCDS34245.2

UniProtKB/Swiss-Prot

Q6NVU9, Q8IXM1, Q9HD13, Q9HD14, Q9HD15

UniProtKB/TrEMBL

B3KNT3

Related

ENSP00000337513.6, ENST00000336283.9

Conserved Domains (1) summary

pfam07304
Location:71 → 207

SRA1; Steroid receptor RNA activator (SRA1)
NM_001253764.2 → NP_001240693.1 steroid receptor RNA activator 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) retains a segment in the 5' coding region and lacks a downstream coding exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct segment in the N-terminal region, compared to isoform 1.

Source sequence(s)

AC011399, BC067895, BQ052761, BU553214

Conserved Domains (1) summary

pfam07304
Location:103 → 191

SRA1; Steroid receptor RNA activator (SRA1)

RNA

NR_045586.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF318361, AI140060, BC040043, BQ052761, DQ286291
NR_045587.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) retains a segment in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC011399, BC040043, BC067895, BQ052761, DA311407

Related

ENST00000602775.5