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Yy2 Yy2 transcription factor [ Mus musculus (house mouse) ]

Gene ID: 100073351, updated on 11-Apr-2024

Summary

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Official Symbol
Yy2provided by MGI
Official Full Name
Yy2 transcription factorprovided by MGI
Primary source
MGI:MGI:3837947
See related
Ensembl:ENSMUSG00000091736 AllianceGenome:MGI:3837947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human YY2 (YY2 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
X F4; X 72.57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (156349115..156351981, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (157566119..157568985, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM5 homolog Neighboring gene STARR-seq mESC enhancer starr_48153 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 9 pseudogene Neighboring gene membrane-bound transcription factor peptidase, site 2 Neighboring gene STARR-seq mESC enhancer starr_48154 Neighboring gene STARR-seq mESC enhancer starr_48156 Neighboring gene STARR-positive B cell enhancer ABC_E7709 Neighboring gene STARR-seq mESC enhancer starr_48157 Neighboring gene predicted gene 15173 Neighboring gene STARR-seq mESC enhancer starr_48159 Neighboring gene protein Hikeshi pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro. Klar M, et al. Cell Tissue Res, 2015 Nov. PMID 26350623, Free PMC Article
  2. Role of polypyrimidine tract-binding protein 1/yin yang 2 signaling in regulating vascular smooth muscle cell proliferation and neointima hyperplasia. Wang Z, et al. Toxicol Appl Pharmacol, 2019 Nov 15. PMID 31499192
  3. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Tahmasebi S, et al. Proc Natl Acad Sci U S A, 2016 Nov 1. PMID 27791185, Free PMC Article
  4. Developmental expression profile of the YY2 gene in mice. Drews D, et al. BMC Dev Biol, 2009 Jul 28. PMID 19638226, Free PMC Article
  5. Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2. Kakizaki F, et al. Cancer Sci, 2016 Nov. PMID 27561171, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTBP1 is a critical regulator of vascular smooth muscle cell proliferation and neointima hyperplasia via modulating the expression of YY2.
    Title: Role of polypyrimidine tract-binding protein 1/yin yang 2 signaling in regulating vascular smooth muscle cell proliferation and neointima hyperplasia.
  2. in a transplantation mouse model of liver metastases, expression of Yy2 (and therefore of Aes) is downregulated
    Title: Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
  3. both the up- and down-regulation of yy2 significantly impairs the outgrowth of the major neurite of primary hippocampal neurons and the numbers of neuronal processes in proximate extensions
    Title: Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro.
  4. Yy2 expression in the heart and lung is constitutively expressed during embryogenesis and in adult mice. Developmental changes of yy2 transcription became obvious in various areas of the brain.
    Title: Developmental expression profile of the YY2 gene in mice.
  5. the novel factor YY2 antagonizes the negative actions exerted by YY1
    Title: Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor YY2
Names
YY-2
yin and yang 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098723.1 → NP_001092193.1  transcription factor YY2

    See identical proteins and their annotated locations for NP_001092193.1

    Status: VALIDATED

    Source sequence(s)
    AK161451
    Consensus CDS
    CCDS53233.1
    UniProtKB/Swiss-Prot
    Q3TTC2, Q8CBG3
    Related
    ENSMUSP00000070112.5, ENSMUST00000065806.5
    Conserved Domains (4) summary
    COG5048
    Location:289 → 378
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:289 → 311
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:333 → 360
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    156349115..156351981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TTC2.1 GenPept UniProtKB/Swiss-Prot:Q3TTC2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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