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Cyp2j11 cytochrome P450, family 2, subfamily j, polypeptide 11 [ Mus musculus (house mouse) ]

Gene ID: 100066, updated on 27-Feb-2024

Summary

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Official Symbol
Cyp2j11provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily j, polypeptide 11provided by MGI
Primary source
MGI:MGI:2140224
See related
Ensembl:ENSMUSG00000066097 AllianceGenome:MGI:2140224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp2j11-ps
Summary
Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 45.3) See more
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Genomic context

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Location:
4 C5; 4 44.44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (96182745..96236930, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96294508..96348693, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 7 Neighboring gene cytochrome P450, family 2, subfamily j, member 15, pseudogene Neighboring gene STARR-seq mESC enhancer starr_10821 Neighboring gene STARR-seq mESC enhancer starr_10822 Neighboring gene STARR-seq mESC enhancer starr_10823 Neighboring gene STARR-seq mESC enhancer starr_10824 Neighboring gene cytochrome P450, family 2, subfamily j, member 14, pseudogene Neighboring gene STARR-seq mESC enhancer starr_10825 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC91118

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonic acid 11,12-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid 14,15-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables linoleic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in icosanoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450, family 2, subfamily j, polypeptide 11
Names
cytochrome P450, 2j11
cytochrome P450, family 2, subfamily j, polypeptide 11, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004141.2 → NP_001004141.2  cytochrome P450, family 2, subfamily j, polypeptide 11

    See identical proteins and their annotated locations for NP_001004141.2

    Status: VALIDATED

    Source sequence(s)
    AK143983, AW260720, BC080831
    Consensus CDS
    CCDS38814.1
    UniProtKB/TrEMBL
    Q3UNV2, Q66JP5
    Related
    ENSMUSP00000132180.2, ENSMUST00000015368.8
    Conserved Domains (1) summary
    pfam00067
    Location:44 → 499
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    96182745..96236930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502615.1 → XP_006502678.1  cytochrome P450, family 2, subfamily j, polypeptide 11 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:4 → 394
    p450; Cytochrome P450

  2. XM_011240375.3 → XP_011238677.1  cytochrome P450, family 2, subfamily j, polypeptide 11 isoform X2

    Conserved Domains (1) summary
    cl12078
    Location:44 → 220
    p450; Cytochrome P450

  3. XM_011240376.3 → XP_011238678.1  cytochrome P450, family 2, subfamily j, polypeptide 11 isoform X3

    Conserved Domains (1) summary
    cl12078
    Location:44 → 235
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version

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