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Lrrc19 leucine rich repeat containing 19 [ Mus musculus (house mouse) ]

Gene ID: 100061, updated on 11-Apr-2024

Summary

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Official Symbol
Lrrc19provided by MGI
Official Full Name
leucine rich repeat containing 19provided by MGI
Primary source
MGI:MGI:2140219
See related
Ensembl:ENSMUSG00000049799 AllianceGenome:MGI:2140219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130022A01Rik
Summary
Enables signaling receptor activity. Involved in several processes, including TRAF-mediated signal transduction; host-mediated regulation of intestinal microbiota composition; and regulation of inflammatory response. Acts upstream of or within positive regulation of NIK/NF-kappaB signaling and toll-like receptor signaling pathway. Located in plasma membrane. Orthologous to human LRRC19 (leucine rich repeat containing 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 14.5), large intestine adult (RPKM 4.0) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C5; 4 43.34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94523958..94538381, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94635721..94650144, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10788 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene phospholipase A2, activating protein Neighboring gene STARR-positive B cell enhancer ABC_E3497 Neighboring gene H3.5 histone Neighboring gene intraflagellar transport 74 Neighboring gene STARR-seq mESC enhancer starr_10791 Neighboring gene microRNA 872 Neighboring gene predicted gene, 40205

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin. Su X, et al. Inflamm Bowel Dis, 2021 Jul 27. PMID 33501933
  2. Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice. Sun J, et al. Organogenesis, 2018 Jan 2. PMID 29461900, Free PMC Article
  3. LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. Su X, et al. Nat Commun, 2014 Jul 16. PMID 25026888
  4. LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines. Chai L, et al. Biochem Biophys Res Commun, 2009 Oct 23. PMID 19679103
  5. The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation. Cao S, et al. Cell Rep, 2016 Feb 2. PMID 26776522, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis.
    Title: Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis.
  2. LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-zeta and PKCiota/lambda to Reduce Expression of ZO1, ZO3, and Occludin.
    Title: LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
  3. LRRC19 could be a potential therapeutic target for pressure ulcers.
    Title: Suppression of LRRC19 promotes cutaneous wound healing in pressure ulcers in mice.
  4. LRRC19 deficiency impairs the gut immune system and host-microbiota interactions.
    Title: The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation.
  5. LRRC19 may play an important role in inducing innate immune responses in certain tissues such as the kidney.
    Title: LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in host-mediated regulation of intestinal microbiota composition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interleukin-8 production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within interleukin-8 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat-containing protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356281.1 → NP_001343210.1  leucine-rich repeat-containing protein 19 precursor

    Status: VALIDATED

    Source sequence(s)
    AK033594, AK165421, AL732597
    Consensus CDS
    CCDS18360.1
    UniProtKB/Swiss-Prot
    B1AWG3, Q6P8J1, Q8BZT5
    Related
    ENSMUSP00000102718.2, ENSMUST00000107101.2
    Conserved Domains (4) summary
    smart00082
    Location:174 → 211
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:73 → 96
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:96 → 155
    LRR_8; Leucine rich repeat
    pfam15176
    Location:251 → 364
    LRR19-TM; Leucine-rich repeat family 19 TM domain

  2. NM_175305.5 → NP_780514.1  leucine-rich repeat-containing protein 19 precursor

    See identical proteins and their annotated locations for NP_780514.1

    Status: VALIDATED

    Source sequence(s)
    AK033594, AK165421
    Consensus CDS
    CCDS18360.1
    UniProtKB/Swiss-Prot
    B1AWG3, Q6P8J1, Q8BZT5
    Related
    ENSMUSP00000056094.3, ENSMUST00000053419.9
    Conserved Domains (4) summary
    smart00082
    Location:174 → 211
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:73 → 96
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:96 → 155
    LRR_8; Leucine rich repeat
    pfam15176
    Location:251 → 364
    LRR19-TM; Leucine-rich repeat family 19 TM domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    94523958..94538381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502614.4 → XP_006502677.1  leucine-rich repeat-containing protein 19 isoform X1

    See identical proteins and their annotated locations for XP_006502677.1

    UniProtKB/Swiss-Prot
    B1AWG3, Q6P8J1, Q8BZT5
    Conserved Domains (4) summary
    smart00082
    Location:174 → 211
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:73 → 96
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:96 → 155
    LRR_8; Leucine rich repeat
    pfam15176
    Location:251 → 364
    LRR19-TM; Leucine-rich repeat family 19 TM domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZT5.1 GenPept UniProtKB/Swiss-Prot:Q8BZT5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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