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Tigit T cell immunoreceptor with Ig and ITIM domains [ Mus musculus (house mouse) ]

Gene ID: 100043314, updated on 21-Apr-2024

Summary

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Official Symbol
Tigitprovided by MGI
Official Full Name
T cell immunoreceptor with Ig and ITIM domainsprovided by MGI
Primary source
MGI:MGI:3642260
See related
Ensembl:ENSMUSG00000071552 AllianceGenome:MGI:3642260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vstm3
Summary
Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 1.9), small intestine adult (RPKM 1.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B4; 16 28.44 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43469224..43485494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43626137..43665125, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 20 Neighboring gene STARR-seq mESC enhancer starr_40880 Neighboring gene predicted gene 15713 Neighboring gene STARR-seq mESC enhancer starr_40881 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43507109-43507410 Neighboring gene STARR-seq mESC enhancer starr_40882 Neighboring gene STARR-seq mESC enhancer starr_40883 Neighboring gene STARR-seq mESC enhancer starr_40885 Neighboring gene STARR-positive B cell enhancer ABC_E7450 Neighboring gene STARR-positive B cell enhancer ABC_E4170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:43690256-43690365 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43698828-43699128 Neighboring gene STARR-seq mESC enhancer starr_40886 Neighboring gene STARR-positive B cell enhancer ABC_E1923 Neighboring gene microRNA 568 Neighboring gene predicted gene, 53956 Neighboring gene STARR-seq mESC enhancer starr_40887 Neighboring gene dopamine receptor D3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Studying TIGIT activity against tumors through the generation of knockout mice. Rishiq A, et al. Oncoimmunology, 2023. PMID 37261087, Free PMC Article
  2. Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis. Gao Y, et al. PLoS Pathog, 2023 Mar. PMID 36930687, Free PMC Article
  3. TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A-Producing CD4(+) Tissue-Resident Memory T Cells. Chen B, et al. Front Immunol, 2022. PMID 35844584, Free PMC Article
  4. TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy. Zhang W, et al. JCI Insight, 2021 Jun 8. PMID 34100383, Free PMC Article
  5. Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Toxoplasma gondii Infection. Aldridge DL, et al. Immunohorizons, 2021 Jun 4. PMID 34088852

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIGIT regulates CD4[+] T cell immunity against polymicrobial sepsis.
    Title: TIGIT regulates CD4(+) T cell immunity against polymicrobial sepsis.
  2. TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes.
    Title: TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes.
  3. Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies.
    Title: Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies.
  4. IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection.
    Title: IL-21 collaborates with anti-TIGIT to restore NK cell function in chronic HBV infection.
  5. Dynamic changes in TIGIT expression on the T-cell surface and TIGIT-mediated T-cell dysfunction in the brains of mice with chronic Toxoplasma gondii infection.
    Title: Dynamic changes in TIGIT expression on the T-cell surface and TIGIT-mediated T-cell dysfunction in the brains of mice with chronic Toxoplasma gondii infection.
  6. [The number of TIGIT[+]CD8[+] T cells increases but their cytokine secretion decreases in the lungs of Plasmodium yoelii infected mice].
    Title: [The number of TIGIT(+)CD8(+) T cells increases but their cytokine secretion decreases in the lungs of Plasmodium yoelii infected mice].
  7. Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
    Title: Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection.
  8. Studying TIGIT activity against tumors through the generation of knockout mice.
    Title: Studying TIGIT activity against tumors through the generation of knockout mice.
  9. TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy.
    Title: TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy.
  10. Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis.
    Title: Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of interleukin-12 production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-10 production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
T-cell immunoreceptor with Ig and ITIM domains
Names
V-set and transmembrane domain containing 3
V-set and transmembrane domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146325.1 → NP_001139797.1  T-cell immunoreceptor with Ig and ITIM domains precursor

    See identical proteins and their annotated locations for NP_001139797.1

    Status: VALIDATED

    Source sequence(s)
    AC120871, CV307751, EU675311
    Consensus CDS
    CCDS49852.1
    UniProtKB/Swiss-Prot
    P86176
    UniProtKB/TrEMBL
    A0A0B4J1G6
    Related
    ENSMUSP00000093770.5, ENSMUST00000096065.6
    Conserved Domains (2) summary
    smart00410
    Location:32 → 127
    IG_like; Immunoglobulin like
    cl11960
    Location:40 → 128
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    43469224..43485494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316834.3 → XP_017172323.1  T-cell immunoreceptor with Ig and ITIM domains isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:40 → 128
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P86176.1 GenPept UniProtKB/Swiss-Prot:P86176

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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