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Thoc2l THO complex subunit 2-like [ Mus musculus (house mouse) ]

Gene ID: 100042165, updated on 8-Mar-2024

Summary

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Official Symbol
Thoc2lprovided by MGI
Official Full Name
THO complex subunit 2-likeprovided by MGI
Primary source
MGI:MGI:3040669
See related
Ensembl:ENSMUSG00000097392 AllianceGenome:MGI:3040669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm3179; AI451450; 1110004B06Rik; D930016D06Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in neuron development; poly(A)+ mRNA export from nucleus; and viral mRNA export from host cell nucleus. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.9), CNS E14 (RPKM 1.4) and 28 other tissues See more
Orthologs
all
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Genomic context

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See Thoc2l in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (104656172..104702073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (104508350..104554207)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Spp1 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_13825 Neighboring gene secreted phosphoprotein 1 Neighboring gene STARR-seq mESC enhancer starr_13829 Neighboring gene STARR-seq mESC enhancer starr_13830 Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene STARR-positive B cell enhancer ABC_E4770 Neighboring gene STARR-seq mESC enhancer starr_13832 Neighboring gene zinc finger protein 33B Neighboring gene predicted gene, 54331 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene predicted gene, 31255

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152
  2. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  3. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in generation of neurons ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of THO complex ISO
Inferred from Sequence Orthology
more info
  
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC100042165

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166581.2 → NP_001160053.1  uncharacterized protein LOC100042165

    Status: VALIDATED

    Source sequence(s)
    AC123687
    Consensus CDS
    CCDS51580.1
    UniProtKB/TrEMBL
    E9Q5E2
    Related
    ENSMUSP00000159295.2, ENSMUST00000239420.2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

RNA

  1. NR_164628.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123687

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    104656172..104702073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164675.1 → XP_036020568.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  2. XM_036164678.1 → XP_036020571.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  3. XM_036164679.1 → XP_036020572.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  4. XM_036164676.1 → XP_036020569.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  5. XM_036164673.1 → XP_036020566.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  6. XM_036164672.1 → XP_036020565.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  7. XM_036164677.1 → XP_036020570.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Related
    ENSMUSP00000130629.2, ENSMUST00000096452.7
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus

  8. XM_036164674.1 → XP_036020567.1  uncharacterized protein LOC100042165 isoform X1

    UniProtKB/TrEMBL
    E9Q5E2
    Conserved Domains (3) summary
    pfam11262
    Location:874 → 1173
    Tho2; Transcription factor/nuclear export subunit protein 2
    pfam11732
    Location:568 → 642
    Thoc2; Transcription- and export-related complex subunit
    pfam16134
    Location:13 → 566
    THOC2_N; THO complex subunit 2 N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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