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Nrg2 neuregulin 2 [ Mus musculus (house mouse) ]

Gene ID: 100042150, updated on 8-Mar-2024

Summary

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Official Symbol
Nrg2provided by MGI
Official Full Name
neuregulin 2provided by MGI
Primary source
MGI:MGI:1098246
See related
Ensembl:ENSMUSG00000060275 AllianceGenome:MGI:1098246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Don1; NTAK
Summary
Predicted to enable ErbB-3 class receptor binding activity; epidermal growth factor receptor binding activity; and epidermal growth factor-activated receptor activity. Predicted to be involved in several processes, including epidermal growth factor receptor signaling pathway; intracellular signal transduction; and regulation of synapse organization. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in epidermis; heart; mammary gland primordium; nervous system; and surface ectoderm. Orthologous to human NRG2 (neuregulin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 3.5), ovary adult (RPKM 2.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B2; 18 19.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36147634..36332754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36014581..36197532, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330008A17 gene Neighboring gene STARR-positive B cell enhancer ABC_E776 Neighboring gene predicted gene, 36416 Neighboring gene pleckstrin and Sec7 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_44271 Neighboring gene STARR-seq mESC enhancer starr_44272 Neighboring gene predicted gene, 41694 Neighboring gene RIKEN cDNA 4930471G03 gene Neighboring gene STARR-seq mESC enhancer starr_44273 Neighboring gene STARR-seq mESC enhancer starr_44274 Neighboring gene STARR-seq mESC enhancer starr_44276 Neighboring gene predicted gene, 41695 Neighboring gene purine rich element binding protein A Neighboring gene IgA inducing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders. Yan L, et al. Mol Psychiatry, 2018 May. PMID 28322273, Free PMC Article
  2. Generation and characterization of neuregulin-2-deficient mice. Britto JM, et al. Mol Cell Biol, 2004 Sep. PMID 15340081, Free PMC Article
  3. Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons. Longart M, et al. J Comp Neurol, 2004 Apr 26. PMID 15048684
  4. Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli. Mautino B, et al. Protein Expr Purif, 2004 May. PMID 15039062
  5. Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA. Yamada K, et al. Gene, 2000 Sep 5. PMID 10974560

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteolytic Processing of Neuregulin 2.
    Title: Proteolytic Processing of Neuregulin 2.
  2. Findings reveal a novel role for NRG2 in the modulation of behaviors with relevance to psychiatric disorders.
    Title: Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.
  3. Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
    Title: A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
  4. in vivo NRG-2 activity differs substantially from that of NRG-1, and it is not essential for normal development
    Title: Generation and characterization of neuregulin-2-deficient mice.
  5. The distinct temporal, regional, and subcellular expression of NRG-2 in the developing brain suggests its unique and nonredundant role in neural function.
    Title: Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons.
  6. identify NRG2 as a factor capable of promoting subventricular zone proliferation, leading to the formation of new neurons in vivo
    Title: The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ErbB-3 class receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ErbB-4 class receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables epidermal growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERBB2-ERBB3 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ERBB4 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ERBB4 signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in ERBB4-ERBB4 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pro-neuregulin-2, membrane-bound isoform
Names
pro-NRG2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167891.3 → NP_001161363.3  pro-neuregulin-2, membrane-bound isoform isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127350, AC131191, AC141471
    Consensus CDS
    CCDS50255.1
    UniProtKB/Swiss-Prot
    P56974
    UniProtKB/TrEMBL
    D3YZR2
    Related
    ENSMUSP00000111378.2, ENSMUST00000115713.9
    Conserved Domains (2) summary
    pfam02158
    Location:441 → 838
    Neuregulin; Neuregulin family
    cd05750
    Location:248 → 339
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

  2. NM_001382420.1 → NP_001369349.1  pro-neuregulin-2, membrane-bound isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127350, AC131191, AC141471
    UniProtKB/Swiss-Prot
    P56974
    Conserved Domains (3) summary
    PHA02887
    Location:354 → 397
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:443 → 840
    Neuregulin; Neuregulin family
    cd05750
    Location:248 → 339
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36147634..36332754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250231.2 → XP_030106091.1  pro-neuregulin-2, membrane-bound isoform isoform X3

    Conserved Domains (1) summary
    pfam02158
    Location:58 → 454
    Neuregulin; Neuregulin family

  2. XM_030250234.2 → XP_030106094.1  pro-neuregulin-2, membrane-bound isoform isoform X5

    Conserved Domains (1) summary
    pfam02158
    Location:47 → 443
    Neuregulin; Neuregulin family

  3. XM_011246789.3 → XP_011245091.1  pro-neuregulin-2, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A6I8MWW5
    Related
    ENSMUSP00000159288.2, ENSMUST00000239409.2
    Conserved Domains (3) summary
    cd05750
    Location:50 → 123
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
    PHA02887
    Location:140 → 183
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:229 → 625
    Neuregulin; Neuregulin family

  4. XM_030250232.1 → XP_030106092.1  pro-neuregulin-2, membrane-bound isoform isoform X4

    Conserved Domains (1) summary
    pfam02158
    Location:50 → 446
    Neuregulin; Neuregulin family

  5. XM_011246790.4 → XP_011245092.1  pro-neuregulin-2, membrane-bound isoform isoform X5

    See identical proteins and their annotated locations for XP_011245092.1

    Conserved Domains (1) summary
    pfam02158
    Location:47 → 443
    Neuregulin; Neuregulin family

  6. XM_006525462.5 → XP_006525525.1  pro-neuregulin-2, membrane-bound isoform isoform X1

    UniProtKB/Swiss-Prot
    P56974
    Conserved Domains (3) summary
    cd05750
    Location:264 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
    PHA03099
    Location:340 → 428
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam02158
    Location:435 → 831
    Neuregulin; Neuregulin family

  7. XM_036160908.1 → XP_036016801.1  pro-neuregulin-2, membrane-bound isoform isoform X6

    Conserved Domains (1) summary
    pfam02158
    Location:39 → 436
    Neuregulin; Neuregulin family

  8. XM_006525466.5 → XP_006525529.1  pro-neuregulin-2, membrane-bound isoform isoform X7

    Conserved Domains (2) summary
    cd05750
    Location:264 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
    PHA02887
    Location:354 → 394
    PHA02887; EGF-like protein; Provisional

  9. XM_011246792.4 → XP_011245094.1  pro-neuregulin-2, membrane-bound isoform isoform X8

    Conserved Domains (2) summary
    cd05750
    Location:264 → 337
    Ig_Pro_neuregulin; Immunoglobulin (Ig)-like domain in neuregulins (NRGs)
    PHA02887
    Location:354 → 394
    PHA02887; EGF-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56974.1 GenPept UniProtKB/Swiss-Prot:P56974

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