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Amd2 S-adenosylmethionine decarboxylase 2 [ Mus musculus (house mouse) ]

Gene ID: 100041585, updated on 3-Apr-2024

Summary

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Official Symbol
Amd2provided by MGI
Official Full Name
S-adenosylmethionine decarboxylase 2provided by MGI
Primary source
MGI:MGI:1333111
See related
Ensembl:ENSMUSG00000063953 AllianceGenome:MGI:1333111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amd1; Amd3; AdoMetDC
Summary
Enables adenosylmethionine decarboxylase activity. Predicted to be involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to act upstream of or within polyamine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
10 B1; 10 19.13 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (35584687..35587887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (35708691..35711891, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26292 Neighboring gene STARR-seq mESC enhancer starr_26293 Neighboring gene STARR-seq mESC enhancer starr_26294 Neighboring gene STARR-seq mESC enhancer starr_26296 Neighboring gene STARR-seq mESC enhancer starr_26297 Neighboring gene STARR-seq mESC enhancer starr_26298 Neighboring gene STARR-seq mESC enhancer starr_26299 Neighboring gene STARR-seq mESC enhancer starr_26300 Neighboring gene predicted gene, 26341 Neighboring gene STARR-seq mESC enhancer starr_26301 Neighboring gene vacuolar protein sorting 54 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26302 Neighboring gene STARR-seq mESC enhancer starr_26303 Neighboring gene STARR-seq mESC enhancer starr_26304 Neighboring gene STARR-seq mESC enhancer starr_26305 Neighboring gene STARR-seq mESC enhancer starr_26306 Neighboring gene STARR-seq mESC enhancer starr_26308 Neighboring gene STARR-seq mESC enhancer starr_26309 Neighboring gene STARR-seq mESC enhancer starr_26310 Neighboring gene STARR-seq mESC enhancer starr_26311 Neighboring gene STARR-seq mESC enhancer starr_26312 Neighboring gene STARR-seq mESC enhancer starr_26313 Neighboring gene STARR-seq mESC enhancer starr_26314 Neighboring gene STARR-seq mESC enhancer starr_26315 Neighboring gene STARR-seq mESC enhancer starr_26316 Neighboring gene STARR-seq mESC enhancer starr_26317 Neighboring gene STARR-seq mESC enhancer starr_26318 Neighboring gene predicted gene, 40623 Neighboring gene STARR-seq mESC enhancer starr_26319 Neighboring gene STARR-seq mESC enhancer starr_26320 Neighboring gene STARR-seq mESC enhancer starr_26322 Neighboring gene STARR-seq mESC enhancer starr_26323 Neighboring gene STARR-seq mESC enhancer starr_26324 Neighboring gene STARR-seq mESC enhancer starr_26325 Neighboring gene VISTA enhancer mm693 Neighboring gene STARR-seq mESC enhancer starr_26326 Neighboring gene STARR-seq mESC enhancer starr_26327 Neighboring gene STARR-seq mESC enhancer starr_26330 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 5 Neighboring gene predicted gene, 22554

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and sequencing of an intronless mouse S-adenosylmethionine decarboxylase gene coding for a functional enzyme strongly expressed in the liver. Persson K, et al. J Biol Chem, 1995 Mar 10. PMID 7890685
  2. Mouse chromosome 19. Guénet JL. Mamm Genome, 1991. PMID 1823552
  3. The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene (Odc) on chromosome 12 and is present in distantly related species of the genus Mus. Persson K, et al. Mamm Genome, 1999 Aug. PMID 10430664
  4. Structure and activity of mouse S-adenosylmethionine decarboxylase gene promoters and properties of the encoded proteins. Nishimura K, et al. Biochem J, 1998 Jun 15. PMID 9620866, Free PMC Article
  5. Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. Sah RK, et al. PLoS One, 2019. PMID 31291246, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenosylmethionine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylmethionine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenosylmethionine decarboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables putrescine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables putrescine binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in spermine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
S-adenosylmethionine decarboxylase proenzyme 2
Names
AdoMetDC 1
S-adenosylmethionine decarboxylase proenzyme 1
SAMDC 1
SAMDC 2
adenosylmethionine decarboxylase 2
adoMetDC 2
NP_031470.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007444.3 → NP_031470.3  S-adenosylmethionine decarboxylase proenzyme 2

    See identical proteins and their annotated locations for NP_031470.3

    Status: VALIDATED

    Source sequence(s)
    AC147238
    Consensus CDS
    CCDS48536.1
    UniProtKB/Swiss-Prot
    D3Z6H8
    Related
    ENSMUSP00000079703.3, ENSMUST00000080898.4
    Conserved Domains (1) summary
    pfam01536
    Location:4 → 325
    SAM_decarbox; Adenosylmethionine decarboxylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    35584687..35587887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_007145.1: Suppressed sequence

    Description
    NG_007145.1: This RefSeq was permanently suppressed because there is evidence that this gene encodes a functional protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z6H8.1 GenPept UniProtKB/Swiss-Prot:D3Z6H8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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