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Ly6c2 lymphocyte antigen 6 family memberC2 [ Mus musculus (house mouse) ]

Gene ID: 100041546, updated on 11-Apr-2024

Summary

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Official Symbol
Ly6c2provided by MGI
Official Full Name
lymphocyte antigen 6 family memberC2provided by MGI
Primary source
MGI:MGI:3712069
See related
Ensembl:ENSMUSG00000022584 AllianceGenome:MGI:3712069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-6C2; Ly-6C.2
Summary
Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Located in cell surface. Orthologous to human LY6H (lymphocyte antigen 6 family member H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 66.9), mammary gland adult (RPKM 63.7) and 21 other tissues See more
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Genomic context

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Location:
15 D3; 15 34.29 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (74980010..74983820, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75108161..75112066, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member C1 Neighboring gene predicted gene 5960 Neighboring gene STARR-seq mESC enhancer starr_39009 Neighboring gene STARR-positive B cell enhancer ABC_E11591 Neighboring gene lymphocyte antigen 6 family member A2 Neighboring gene lymphocyte antigen 6 family member G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiple expression of Ly-6C and accumulation of a Ly-6C pre-mRNA in activated macrophages involved in rejection of an allografted tumor. Takikawa O, et al. Biochem Biophys Res Commun, 1996 Sep 4. PMID 8806622
  2. N-terminal and cDNA characterization of murine lymphocyte antigen Ly-6C.2. Palfree RG, et al. J Immunol, 1988 Jan 1. PMID 3335781
  3. Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection. Świerczek-Lasek B, et al. Cells, 2022 Sep 12. PMID 36139418, Free PMC Article
  4. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Ramachandran P, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23100531, Free PMC Article
  5. Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1. Stier MT, et al. Mamm Genome, 2012 Apr. PMID 22101863, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC103163

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte antigen 6C2
Names
lymphocyte antigen 6 complex, locus C2
lymphocyte antigen 6C precursor (Ly-6C)
lymphocyte differentiation antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099217.2 → NP_001092687.1  lymphocyte antigen 6C2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001092687.1

    Status: VALIDATED

    Source sequence(s)
    AC116498
    Consensus CDS
    CCDS49638.1
    UniProtKB/Swiss-Prot
    P0CW03
    UniProtKB/TrEMBL
    A0A087WRP7
    Related
    ENSMUSP00000098110.4, ENSMUST00000100542.10
    Conserved Domains (1) summary
    pfam00021
    Location:29 → 102
    UPAR_LY6; u-PAR/Ly-6 domain

  2. NM_001357693.2 → NP_001344622.1  lymphocyte antigen 6C2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    Consensus CDS
    CCDS49638.1
    UniProtKB/Swiss-Prot
    P0CW03
    UniProtKB/TrEMBL
    A0A087WRP7
    Related
    ENSMUSP00000139556.2, ENSMUST00000191451.2
    Conserved Domains (1) summary
    pfam00021
    Location:29 → 102
    UPAR_LY6; u-PAR/Ly-6 domain

  3. NM_001415992.1 → NP_001402921.1  lymphocyte antigen 6C2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    UniProtKB/Swiss-Prot
    P0CW03

  4. NM_001415993.1 → NP_001402922.1  lymphocyte antigen 6C2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    UniProtKB/Swiss-Prot
    P0CW03

  5. NM_001415994.1 → NP_001402923.1  lymphocyte antigen 6C2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    UniProtKB/Swiss-Prot
    P0CW03

  6. NM_001415995.1 → NP_001402924.1  lymphocyte antigen 6C2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498

  7. NM_001415996.1 → NP_001402925.1  lymphocyte antigen 6C2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498
    UniProtKB/Swiss-Prot
    P0CW03
    Related
    ENSMUSP00000140825.2, ENSMUST00000188214.7

  8. NM_001415997.1 → NP_001402926.1  lymphocyte antigen 6C2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498

  9. NM_001415998.1 → NP_001402927.1  lymphocyte antigen 6C2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116498

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    74980010..74983820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CW03.1 GenPept UniProtKB/Swiss-Prot:P0CW03

Gene LinkOut

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