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Cyp3a59 cytochrome P450, family 3, subfamily a, polypeptide 59 [ Mus musculus (house mouse) ]

Gene ID: 100041449, updated on 8-Feb-2024

Summary

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Official Symbol
Cyp3a59provided by MGI
Official Full Name
cytochrome P450, family 3, subfamily a, polypeptide 59provided by MGI
Primary source
MGI:MGI:3769707
See related
Ensembl:ENSMUSG00000061292 AllianceGenome:MGI:3769707
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including caffeine oxidase activity; iron ion binding activity; and monooxygenase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to human CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 11.2) See more
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Genomic context

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See Cyp3a59 in Genome Data Viewer
Location:
5 G3; 5 85.17 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146016018..146051788)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146079208..146114978)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8454 Neighboring gene STARR-seq mESC enhancer starr_14839 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene predicted gene 5565 Neighboring gene predicted gene 6309

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Kazuki Y, et al. Hum Mol Genet, 2013 Feb 1. PMID 23125282
  2. Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. van Herwaarden AE, et al. J Clin Invest, 2007 Nov. PMID 17975676, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables estrogen 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables estrogen 2-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables retinoic acid 4-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 6-beta-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables testosterone 6-beta-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450, family 3, subfamily a, polypeptide 59
Names
cytochrome P450, subfamily 3A, polypeptide 59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105160.1 → NP_001098630.1  cytochrome P450, family 3, subfamily a, polypeptide 59

    Status: PROVISIONAL

    Source sequence(s)
    AC104856
    Consensus CDS
    CCDS39390.1
    UniProtKB/TrEMBL
    D3Z2W7, Q9QXK4
    Related
    ENSMUSP00000049494.9, ENSMUST00000035571.10
    Conserved Domains (1) summary
    pfam00067
    Location:39 → 493
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146016018..146051788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254003.1 → XP_030109863.1  cytochrome P450, family 3, subfamily a, polypeptide 59 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:23 → 341
    p450; Cytochrome P450

RNA

  1. XR_868673.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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