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Dynlt1c dynein light chain Tctex-type 1C [ Mus musculus (house mouse) ]

Gene ID: 100040563, updated on 3-Apr-2024

Summary

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Official Symbol
Dynlt1cprovided by MGI
Official Full Name
dynein light chain Tctex-type 1Cprovided by MGI
Primary source
MGI:MGI:3807476
See related
Ensembl:ENSMUSG00000000579 AllianceGenome:MGI:3807476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AGS2; Dynlt1; Tctel1; Tctex1; Dynlt1d; Tctex-1; 100040603
Summary
Predicted to enable identical protein binding activity and protein C-terminus binding activity. Predicted to be involved in several processes, including intracellular transport of viral protein in host cell; neuron projection development; and positive regulation of Rac protein signal transduction. Predicted to be located in several cellular components, including axonal growth cone; cytoplasmic microtubule; and lamellipodium. Predicted to be part of cytoplasmic dynein complex. Orthologous to human DYNLT1 (dynein light chain Tctex-type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 875.5), CNS E14 (RPKM 291.0) and 24 other tissues See more
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Genomic context

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See Dynlt1c in Genome Data Viewer
Location:
17 A1; 17 4.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6869178..6877078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6601779..6607891)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2808 Neighboring gene predicted gene, 29721 Neighboring gene predicted gene, 53224 Neighboring gene STARR-positive B cell enhancer mm9_chr17:6657759-6658060 Neighboring gene STARR-positive B cell enhancers mm9_chr17:6806288-6806589 and mm9_chr17:6654863-6655163 Neighboring gene transmembrane protein 181C, pseudogene Neighboring gene STARR-positive B cell enhancers mm9_chr17:6600655-6600955 and mm9_chr17:6860503-6860804 Neighboring gene dynein light chain Tctex-type 1F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. tctex-1: a candidate gene family for a mouse t complex sterility locus. Lader E, et al. Cell, 1989 Sep 8. PMID 2570638
  2. Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. He S, et al. Nat Commun, 2023 Mar 27. PMID 36973253, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon development ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular transport of viral protein in host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in secretory vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein light chain Tctex-type 1C
Names
Activator of G-protein signaling 2
Dynein light chain Tctex-type 1
T-complex testis-specific protein 1
dynein light chain Tctex-type 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166630.1 → NP_001160102.1  dynein light chain Tctex-type 1C isoform 1

    See identical proteins and their annotated locations for NP_001160102.1

    Status: VALIDATED

    Source sequence(s)
    AK168478
    Consensus CDS
    CCDS57042.1
    UniProtKB/Swiss-Prot
    P51807, Q5M8S6
    UniProtKB/TrEMBL
    A1E5T5
    Related
    ENSMUSP00000090644.5, ENSMUST00000092966.5
    Conserved Domains (1) summary
    pfam03645
    Location:16 → 111
    Tctex-1; Tctex-1 family

  2. NM_001414431.1 → NP_001401360.1  dynein light chain Tctex-type 1C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167249

  3. NM_001414432.1 → NP_001401361.1  dynein light chain Tctex-type 1C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC167249

  4. NM_001414433.1 → NP_001401362.1  dynein light chain Tctex-type 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC167249

  5. NM_001414434.1 → NP_001401363.1  dynein light chain Tctex-type 1C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC167249

  6. NM_001414435.1 → NP_001401364.1  dynein light chain Tctex-type 1C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC167249

  7. NM_001414436.1 → NP_001401365.1  dynein light chain Tctex-type 1C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC167249

  8. NM_001414437.1 → NP_001401366.1  dynein light chain Tctex-type 1C isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC167249

RNA

  1. NR_182436.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC167249

  2. NR_182437.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC167249

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    6869178..6877078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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