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Ildr2 immunoglobulin-like domain containing receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 100039795, updated on 11-Apr-2024

Summary

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Official Symbol
Ildr2provided by MGI
Official Full Name
immunoglobulin-like domain containing receptor 2provided by MGI
Primary source
MGI:MGI:1196370
See related
Ensembl:ENSMUSG00000040612 AllianceGenome:MGI:1196370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ll; Dbsm1; D1Ertd471e; 2810478N18Rik; 3110063L10Rik
Summary
Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; insulin secretion; and response to glucose. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in embryo and retina. Orthologous to human ILDR2 (immunoglobulin like domain containing receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 6.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.3; 1 73.61 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (166081630..166144405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (166254060..166316832)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7772 Neighboring gene glycoprotein A33 transmembrane Neighboring gene STARR-seq mESC enhancer starr_02926 Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene STARR-positive B cell enhancer mm9_chr1:168290436-168290736 Neighboring gene STARR-seq mESC enhancer starr_02930 Neighboring gene STARR-positive B cell enhancer ABC_E11695 Neighboring gene transcriptional adaptor 1 Neighboring gene STARR-seq mESC enhancer starr_02931 Neighboring gene pogo transposable element with KRAB domain Neighboring gene ubiquinol-cytochrome c reductase subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2). Huetter J, et al. Cancer Immunol Res, 2020 Jul. PMID 32312711
  2. ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance. Podojil JR, et al. J Immunol, 2018 Mar 15. PMID 29431690, Free PMC Article
  3. ILDR2 has a negligible role in hepatic steatosis. Millings EJ, et al. PLoS One, 2018. PMID 29847571, Free PMC Article
  4. ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses. Hecht I, et al. J Immunol, 2018 Mar 15. PMID 29431694, Free PMC Article
  5. ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis. Watanabe K, et al. PLoS One, 2013. PMID 23826244, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
    Title: Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
  2. ILDR2 as a novel negative regulator for T cells.
    Title: ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
  3. The potential of ILDR-Fc to provide a promising therapeutic approach for the treatment of autoimmune diseases.
    Title: ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance.
  4. We conclude that ILDR2 plays a negligible role in hepatic steatosis. Rather, hepatic steatosis observed previously in Ildr2 knockdown mice was likely due to shRNA targeting of Dgka and/or other "off-target" genes.
    Title: ILDR2 has a negligible role in hepatic steatosis.
  5. manipulation of Ildr2 expression in liver affects both lipid homeostasis and ER stress pathways.
    Title: ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in pancreas development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in tight junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
immunoglobulin-like domain-containing receptor 2
Names
angulin-3
lisch-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164528.1 → NP_001158000.1  immunoglobulin-like domain-containing receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001158000.1

    Status: VALIDATED

    Source sequence(s)
    AC034122
    Consensus CDS
    CCDS48431.1
    UniProtKB/Swiss-Prot
    B5TVM2, B5TVM3, B5TVM4, B5TVM5, B5TVM6, B5TVM7, B5TVM8, B5TVM9, E9Q9U5
    Related
    ENSMUSP00000107047.2, ENSMUST00000111416.7
    Conserved Domains (2) summary
    pfam05624
    Location:201 → 227
    LSR; Lipolysis stimulated receptor (LSR)
    cl11960
    Location:49 → 182
    Ig; Immunoglobulin domain

  2. NM_001357428.1 → NP_001344357.1  immunoglobulin-like domain-containing receptor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC034122
    Consensus CDS
    CCDS87913.1
    UniProtKB/TrEMBL
    A0A0A6YXV2
    Related
    ENSMUSP00000142152.2, ENSMUST00000194964.6
    Conserved Domains (1) summary
    pfam05624
    Location:201 → 227
    LSR; Lipolysis stimulated receptor (LSR)

  3. NM_001357429.1 → NP_001344358.1  immunoglobulin-like domain-containing receptor 2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC034122
    Consensus CDS
    CCDS87916.1
    UniProtKB/TrEMBL
    A0A0A6YWD2
    Related
    ENSMUSP00000141502.2, ENSMUST00000192732.6

  4. NM_001357430.1 → NP_001344359.1  immunoglobulin-like domain-containing receptor 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC034122
    Consensus CDS
    CCDS87915.1
    UniProtKB/TrEMBL
    A0A0A6YY76
    Related
    ENSMUSP00000142311.2, ENSMUST00000192638.6
    Conserved Domains (1) summary
    pfam05624
    Location:182 → 208
    LSR; Lipolysis stimulated receptor (LSR)

  5. NM_001357431.1 → NP_001344360.1  immunoglobulin-like domain-containing receptor 2 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC034122
    Consensus CDS
    CCDS87914.1
    UniProtKB/TrEMBL
    A0A0A6YVY9
    Related
    ENSMUSP00000141323.2, ENSMUST00000193860.2
    Conserved Domains (1) summary
    cl11960
    Location:132 → 181
    Ig; Immunoglobulin domain

  6. NM_001357432.1 → NP_001344361.1  immunoglobulin-like domain-containing receptor 2 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC034122
    Consensus CDS
    CCDS87912.1
    UniProtKB/TrEMBL
    A0A0A6YY19
    Related
    ENSMUSP00000142240.2, ENSMUST00000195557.6
    Conserved Domains (2) summary
    pfam05624
    Location:201 → 227
    LSR; Lipolysis stimulated receptor (LSR)
    cl11960
    Location:49 → 182
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    166081630..166144405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164352.1 → XP_036020245.1  immunoglobulin-like domain-containing receptor 2 isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:51 → 181
    Ig; Immunoglobulin domain

  2. XM_011238731.3 → XP_011237033.1  immunoglobulin-like domain-containing receptor 2 isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:132 → 181
    Ig; Immunoglobulin domain

  3. XM_006496594.5 → XP_006496657.1  immunoglobulin-like domain-containing receptor 2 isoform X1

    Conserved Domains (2) summary
    pfam05624
    Location:170 → 196
    LSR; Lipolysis stimulated receptor (LSR)
    cl11960
    Location:101 → 150
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5TVM2.2 GenPept UniProtKB/Swiss-Prot:B5TVM2

Gene LinkOut

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