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Mthfsl 5, 10-methenyltetrahydrofolate synthetase-like [ Mus musculus (house mouse) ]

Gene ID: 100039707, updated on 3-Apr-2024

Summary

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Official Symbol
Mthfslprovided by MGI
Official Full Name
5, 10-methenyltetrahydrofolate synthetase-likeprovided by MGI
Primary source
MGI:MGI:3780550
See related
Ensembl:ENSMUSG00000079427 AllianceGenome:MGI:3780550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm2382
Summary
Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ST20-MTHFS (ST20-MTHFS readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 6.6), kidney adult (RPKM 6.4) and 28 other tissues See more
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Genomic context

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See Mthfsl in Genome Data Viewer
Location:
9 E3.1; 9 47.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88567696..88602381, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88685630..88720320, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26567 Neighboring gene predicted gene 29415 Neighboring gene predicted gene, 53509 Neighboring gene STARR-seq mESC enhancer starr_24858 Neighboring gene STARR-seq mESC enhancer starr_24859 Neighboring gene STARR-positive B cell enhancer ABC_E3851 Neighboring gene STARR-positive B cell enhancer ABC_E10574 Neighboring gene STARR-positive B cell enhancer mm9_chr9:88626551-88626852 Neighboring gene predicted gene 10634 Neighboring gene STARR-seq mESC enhancer starr_24860 Neighboring gene B cell leukemia/lymphoma 2 related protein A1d Neighboring gene predicted gene, 53511

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models. Shimizu R, et al. Biochem Biophys Res Commun, 2021 Jan 8. PMID 33348080
  2. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC37660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-formyltetrahydrofolate cyclo-ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in folic acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in folic acid-containing compound biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate interconversion ISO
Inferred from Sequence Orthology
more info
  
involved_in tetrahydrofolate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5, 10-methenyltetrahydrofolate synthetase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128601.1 → NP_001122073.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710
    Consensus CDS
    CCDS52881.1
    UniProtKB/TrEMBL
    L7N466, Q3TYX5
    Related
    ENSMUSP00000108734.4, ENSMUST00000113110.5
    Conserved Domains (1) summary
    pfam01812
    Location:10 → 198
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  2. NM_001359992.1 → NP_001346921.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710
    Consensus CDS
    CCDS90638.1
    UniProtKB/TrEMBL
    Q8R1G5
    Conserved Domains (1) summary
    pfam01812
    Location:1 → 141
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  3. NM_001411334.1 → NP_001398263.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  4. NM_001411335.1 → NP_001398264.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT030710

  5. NM_001411336.1 → NP_001398265.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  6. NM_001411337.1 → NP_001398266.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710
    UniProtKB/TrEMBL
    Q8R1G5
    Related
    ENSMUSP00000150907.2, ENSMUST00000186863.7

  7. NM_001411338.1 → NP_001398267.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710
    UniProtKB/TrEMBL
    Q8R1G5

  8. NM_001411339.1 → NP_001398268.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  9. NM_001411340.1 → NP_001398269.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

RNA

  1. NR_177216.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  2. NR_177217.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  3. NR_177218.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  4. NR_177219.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710
    Related
    ENSMUST00000186721.2

  5. NR_177220.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  6. NR_177221.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  7. NR_177222.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

  8. NR_177223.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163666, CT030710

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    88567696..88602381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154490.1 → XP_036010383.1  5, 10-methenyltetrahydrofolate synthetase-like isoform X1

    Conserved Domains (1) summary
    cl00360
    Location:10 → 126
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

RNA

  1. XR_870748.4 RNA Sequence

  2. XR_870750.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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