H2ab1 H2A.B variant histone 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2ab1provided by MGI
Official Full Name: H2A.B variant histone 1provided by MGI
Primary source: MGI:MGI:3642445
See related: Ensembl:ENSMUSG00000067441 AllianceGenome:MGI:3642445
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1539; H2afb1; Gm14920; H2A.B.3; H2A.Bbd1; H2A.Lap1
Summary: Predicted to enable DNA binding activity. Predicted to be involved in heterochromatin assembly. Predicted to be located in transcriptionally active chromatin. Predicted to be part of nucleosome. Orthologous to several human genes including H2AB1 (H2A.B variant histone 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: X E1; X 49.58 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (115924454..115924801)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (117014757..117015104)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of euchromatin	ISO Inferred from Sequence Orthology more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone H2A

Names: H2A histone family member B1; predicted pseudogene 14920

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102665.1 → NP_001096135.1 histone H2A

See identical proteins and their annotated locations for NP_001096135.1

Status: PROVISIONAL

Source sequence(s)

BX088543

Consensus CDS

CCDS72425.1

UniProtKB/TrEMBL

S4R1E0

Related

ENSMUSP00000138181.2, ENSMUST00000122446.2

Conserved Domains (1) summary

cl23907
Location:25 → 112

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...