Btnl1 butyrophilin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btnl1provided by MGI
Official Full Name: butyrophilin-like 1provided by MGI
Primary source: MGI:MGI:1932027
See related: Ensembl:ENSMUSG00000062638 AllianceGenome:MGI:1932027
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm33; Btnl3; Gm316
Summary: Predicted to enable signaling receptor binding activity. Involved in extrathymic T cell selection. Located in cell surface. Is expressed in ductus deferens; epididymis; ileum; prostate gland; and testis. Orthologous to human BTNL3 (butyrophilin like 3) and BTNL8 (butyrophilin like 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 46.9), large intestine adult (RPKM 46.4) and 2 other tissues See more
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34596097..34605136)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34377123..34386162)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data show that the expression of Btnl1 and Btnl6 is delayed in the murine neonatal gut and that the appearance of the Btnl1 and Btnl6 proteins in the intestinal mucosa associates with the expansion of Vgamma7Vdelta4 TCR IELs
Title: The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine.
Enforced epithelial cell expression of Btnl1 attenuated the cells' response to activated intraepithelial lymphocyte, as evidenced by suppression of IL-6 and other inflammatory mediators.
Title: Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.
BTNL1 is a critical inhibitory molecule for T cell activation and immune diseases.
Title: A butyrophilin family member critically inhibits T cell activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrathymic T cell selection	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrathymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: butyrophilin-like protein 1

Names: NG10; butyrophilin-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111094.1 → NP_001104564.1 butyrophilin-like protein 1 precursor

See identical proteins and their annotated locations for NP_001104564.1

Status: PROVISIONAL

Source sequence(s)

CR974457

Consensus CDS

CCDS50075.1

UniProtKB/Swiss-Prot

A6X8K2, G3UZN0, O70356, Q7TST0

Related

ENSMUSP00000079140.6, ENSMUST00000080254.7

Conserved Domains (4) summary

cd05713
Location:46 → 145

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

smart00410
Location:39 → 144

IG_like; Immunoglobulin like

cl02614
Location:374 → 496

SPRY; SPRY domain

cl11960
Location:156 → 227

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34596097..34605136

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523364.1 → XP_006523427.1 butyrophilin-like protein 1 isoform X1

Conserved Domains (2) summary

cl02614
Location:346 → 468

SPRY; SPRY domain

cl11960
Location:46 → 115

Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_201405.2: Suppressed sequence

Description

NM_201405.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.