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Apela apelin receptor early endogenous ligand [ Mus musculus (house mouse) ]

Gene ID: 100038489, updated on 8-Mar-2024

Summary

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Official Symbol
Apelaprovided by MGI
Official Full Name
apelin receptor early endogenous ligandprovided by MGI
Primary source
MGI:MGI:3642370
See related
Ensembl:ENSMUSG00000079042 AllianceGenome:MGI:3642370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ela; Ende; Elabela; Gm10664
Summary
Predicted to enable apelin receptor binding activity and hormone activity. Involved in circulatory system development and positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. Acts upstream of or within SMAD protein signal transduction. Located in extracellular space. Is expressed in several structures, including embryo ectoderm; embryo endoderm; gut; heart; and metanephros. Used to study pre-eclampsia. Orthologous to human APELA (apelin receptor early endogenous ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 30.1), placenta adult (RPKM 5.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Apela in Genome Data Viewer
Location:
8 B3.1; 8 32.52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65481069..65489970, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (65028417..65037336, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 75 Neighboring gene tripartite motif-containing 60 Neighboring gene tripartite motif-containing 61 Neighboring gene STARR-seq mESC enhancer starr_21646 Neighboring gene STARR-seq mESC enhancer starr_21647 Neighboring gene STARR-seq mESC enhancer starr_21648 Neighboring gene predicted gene, 39183 Neighboring gene STARR-seq mESC enhancer starr_21650 Neighboring gene STARR-seq mESC enhancer starr_21651 Neighboring gene small integral membrane protein 31 Neighboring gene predicted gene 45445

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome. Jin L, et al. FASEB J, 2021 Oct. PMID 34516679
  2. ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway. Chen Z, et al. Cell Death Dis, 2020 Aug 22. PMID 32829380, Free PMC Article
  3. ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury. Xu C, et al. Am J Physiol Renal Physiol, 2020 May 1. PMID 32174138, Free PMC Article
  4. Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System. Jackson M, et al. Stem Cell Reports, 2021 Apr 13. PMID 33667414, Free PMC Article
  5. Expression and functional implications of the renal apelinergic system in rodents. O'Carroll AM, et al. PLoS One, 2017. PMID 28817612, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway.
    Title: ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway.
  2. Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury.
    Title: Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury.
  3. Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.
    Title: Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome.
  4. Antagonistic interaction between ELA and intrarenal renin angiotensin system in the distal nephron that appears to exert a major impact on blood pressure regulation.
    Title: ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury.
  5. loss of Apela signaling impacts early Aplnr-expressing mesodermal populations.
    Title: Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
  6. Elabela but not Apelin knockout pregnant mice exhibit preeclampsia -like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis.
    Title: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
  7. the ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors.
    Title: Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
  8. conclude that apela is present in the adult heart, is upregulated in post-infarction cardiac remodeling, and increases cardiac contractility in an ERK1/2-dependent manner
    Title: Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.
  9. Ende was expressed dynamically and in specific populations of the definitive endoderm from E7.0 to E8.5.
    Title: Expression of two novel transcripts in the mouse definitive endoderm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables apelin receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables hormone activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in apelin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gastrulation IEA
Inferred from Electronic Annotation
more info
  
involved_in heart development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
apelin receptor early endogenous ligand
Names
Protein Elabela
protein Toddler

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297554.2 → NP_001284483.1  apelin receptor early endogenous ligand precursor

    See identical proteins and their annotated locations for NP_001284483.1

    Status: VALIDATED

    Source sequence(s)
    AC102287
    Consensus CDS
    CCDS80883.1
    UniProtKB/Swiss-Prot
    P0DMC4
    Related
    ENSMUSP00000140510.2, ENSMUST00000142822.4
    Conserved Domains (1) summary
    cd20244
    Location:2 → 54
    Toddler; Apelin receptor early endogenous ligand, also called Toddler

  2. NM_001399422.1 → NP_001386351.1  apelin receptor early endogenous ligand precursor

    Status: VALIDATED

    Source sequence(s)
    AC102287
    UniProtKB/Swiss-Prot
    P0DMC4
    Related
    ENSMUSP00000139425.2, ENSMUST00000124790.8
    Conserved Domains (1) summary
    cd20244
    Location:2 → 54
    Toddler; Apelin receptor early endogenous ligand, also called Toddler

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    65481069..65489970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_040692.1: Suppressed sequence

    Description
    NR_040692.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DMC4.1 GenPept UniProtKB/Swiss-Prot:P0DMC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
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