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Spink13 serine peptidase inhibitor, Kazal type 13 [ Mus musculus (house mouse) ]

Gene ID: 100038417, updated on 8-Mar-2024

Summary

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Official Symbol
Spink13provided by MGI
Official Full Name
serine peptidase inhibitor, Kazal type 13provided by MGI
Primary source
MGI:MGI:3642511
See related
Ensembl:ENSMUSG00000073551 AllianceGenome:MGI:3642511
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm10534; Spink5l3
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of acrosome reaction. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Orthologous to human SPINK13 (serine peptidase inhibitor Kazal type 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 1.5) and testis adult (RPKM 0.1) See more
Orthologs
human all
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Genomic context

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Location:
18 E1; 18 35.37 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62740570..62874458, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62607499..62741387, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene F-box protein 38 Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative) Neighboring gene STARR-seq mESC enhancer starr_44775 Neighboring gene STARR-seq mESC enhancer starr_44776 Neighboring gene predicted gene, 41751 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide pseudogene Neighboring gene STARR-seq mESC enhancer starr_44778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:62879723-62879876 Neighboring gene RIKEN cDNA 2700046A07 gene Neighboring gene predicted gene, 36598 Neighboring gene STARR-seq mESC enhancer starr_44779 Neighboring gene STARR-seq mESC enhancer starr_44780 Neighboring gene predicted gene, 41752

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility. Ma L, et al. J Biol Chem, 2013 Apr 5. PMID 23430248, Free PMC Article
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility
    Title: Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease inhibitor Kazal-type 13
Names
serine protease inhibitor Kazal-type 5-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168423.2 → NP_001161895.1  serine protease inhibitor Kazal-type 13 precursor

    See identical proteins and their annotated locations for NP_001161895.1

    Status: PROVISIONAL

    Source sequence(s)
    AK139149
    Consensus CDS
    CCDS50305.1
    UniProtKB/Swiss-Prot
    Q3UTS8
    Related
    ENSMUSP00000095165.4, ENSMUST00000097557.5
    Conserved Domains (1) summary
    smart00280
    Location:55 → 96
    KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    62740570..62874458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525460.4 → XP_006525523.2  serine protease inhibitor Kazal-type 13 isoform X1

    Conserved Domains (1) summary
    smart00280
    Location:95 → 136
    KAZAL; Kazal type serine protease inhibitors

  2. XM_030250229.2 → XP_030106089.1  serine protease inhibitor Kazal-type 13 isoform X2

    UniProtKB/Swiss-Prot
    Q3UTS8
    Conserved Domains (1) summary
    smart00280
    Location:55 → 96
    KAZAL; Kazal type serine protease inhibitors

  3. XM_030250228.2 → XP_030106088.1  serine protease inhibitor Kazal-type 13 isoform X2

    UniProtKB/Swiss-Prot
    Q3UTS8
    Related
    ENSMUSP00000157623.2, ENSMUST00000235190.2
    Conserved Domains (1) summary
    smart00280
    Location:55 → 96
    KAZAL; Kazal type serine protease inhibitors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UTS8.1 GenPept UniProtKB/Swiss-Prot:Q3UTS8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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