Wfdc17 WAP four-disulfide core domain 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wfdc17provided by MGI
Official Full Name: WAP four-disulfide core domain 17provided by MGI
Primary source: MGI:MGI:3649773
See related: Ensembl:ENSMUSG00000069792 AllianceGenome:MGI:3649773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Amwap; Gm11428
Summary: Enables serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 10.5), mammary gland adult (RPKM 8.0) and 15 other tissues See more
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Genomic context

Location:: 11 C; 11 51.22 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83594882..83597095)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83704056..83706269)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone deacetylase-mediated silencing of AMWAP may contribute to cisplatin nephrotoxicity.
Title: Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity.
AMWAP is a counter-regulator of proinflammatory microglia/macrophage activation and a potential modulator of innate immunity in neurodegeneration.
Title: The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: activated macrophage/microglia WAP domain protein

Names: extracellular proteinase inhibitor family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081957.1 → NP_001075426.1 activated macrophage/microglia WAP domain protein precursor

See identical proteins and their annotated locations for NP_001075426.1

Status: VALIDATED

Source sequence(s)

BC089618, W08116

Consensus CDS

CCDS36257.1

UniProtKB/TrEMBL

Q5SSJ1

Related

ENSMUSP00000090511.6, ENSMUST00000092836.6

Conserved Domains (1) summary

cd00199
Location:16 → 75

WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...