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Mdn1 midasin AAA ATPase 1 [ Mus musculus (house mouse) ]

Gene ID: 100019, updated on 5-Mar-2024

Summary

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Official Symbol
Mdn1provided by MGI
Official Full Name
midasin AAA ATPase 1provided by MGI
Primary source
MGI:MGI:1926159
See related
Ensembl:ENSMUSG00000058006 AllianceGenome:MGI:1926159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm135; D4Abb1e; A130070M06; 4833432B22Rik
Summary
Predicted to be involved in rRNA processing and ribosomal large subunit assembly. Predicted to be located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Orthologous to human MDN1 (midasin AAA ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.6), testis adult (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mdn1 in Genome Data Viewer
Location:
4 A5; 4 14.3 cM
Exon count:
102
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32656867..32775217)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32657114..32775217)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene gap junction protein, alpha 10 Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene caspase 8 associated protein 2 Neighboring gene predicted gene, 42267 Neighboring gene LYR motif containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Frey BJ, et al. Nat Genet, 2005 Sep. PMID 16127451
  2. Characterization of the murine gene encoding Aop2 (antioxidant protein 2) and identification of two highly related genes. Phelan SA, et al. Genomics, 1998 Nov 15. PMID 9806838
  3. Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1. Kudo T, et al. Mol Cell Biol, 2004 May. PMID 15121843, Free PMC Article
  4. Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Chambers DM, et al. Genome Res, 1996 Aug. PMID 8858346
  5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
midasin
Names
MIDAS-containing protein
midasin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081392.1 → NP_001074861.1  midasin

    Status: VALIDATED

    Source sequence(s)
    AL805973, AL831774
    Consensus CDS
    CCDS57264.1
    UniProtKB/TrEMBL
    J3QMC5
    Related
    ENSMUSP00000136222.2, ENSMUST00000178134.2
    Conserved Domains (5) summary
    smart00382
    Location:1379 → 1535
    AAA; ATPases associated with a variety of cellular activities
    cd01460
    Location:5309 → 5579
    vWA_midasin; VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The ...
    pfam07728
    Location:1381 → 1535
    AAA_5; AAA domain (dynein-related subfamily)
    cl21455
    Location:1075 → 1211
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22451
    Location:4679 → 4822
    ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    32656867..32775217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537476.4 → XP_006537539.1  midasin isoform X1

    UniProtKB/TrEMBL
    A2ANY6
    Related
    ENSMUSP00000071569.5, ENSMUST00000071642.11
    Conserved Domains (1) summary
    COG5271
    Location:210 → 2308
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_004941785.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133874.1: Suppressed sequence

    Description
    NM_133874.1: This RefSeq was removed because currently there is insufficient support for the transcript.

  2. NM_177666.2: Suppressed sequence

    Description
    NM_177666.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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