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Full record GDS4819

Inhibitor of NEDD8-activating enzyme MLN4924 effect on melanoma cell line

Analysis of A375 melanoma cells treated with small molecule MLN4924 for up to 24 hrs. MLN4924 selectively inhibits Nedd8-activating enzyme resulting in inactivation of the entire family of Cullin-RING ubiquitin ligases. Results provide insight into the molecular basis of MLN4924-induced cell death.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 5 time sets
Platform:
GPL570
Series:
GSE30531
30 Samples
Download data: CEL

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