GEO DataSets

Comparison of glomeruli from kidneys with diabetic nephropathy (DN) and glomeruli from kidneys of healthy individuals. Progression of DN may be due to diminished tissue repair capability.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL8300

Series:

GSE1009

6 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Keywords = Diabetes Keywords = kidney Keywords = glomeruli Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS961

Platform:

GPL8300

6 Samples

Download data: CEL

(Submitter supplied) Although diabetic nephropathy (DN) is the most common cause for end-stage renal disease (ESRD) in western societies, its pathogenesis still remains largely unclear. A different gene pattern of diabetic and healthy kidney cells is one of the probable explanations. Numerous signaling pathways have emerged as important pathophysiological mechanisms for diabetes-induced renal injury. Glomerular cells, as podocytes or mesangial cells, are predominantly involved in the development of diabetic renal lesions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20775

30 Samples

Download data: CEL, CHP

(Submitter supplied) Background: Recent single-cell RNA sequencing (scRNA-seq) analyses have offered much insight into cell-specific gene expression profiles in normal kidneys. However, in diseased kidneys, understanding of changes in specific cells, particularly glomerular cells, remains limited. Methods: To elucidate the glomerular cell–specific gene expression changes in diabetic kidney disease, we performed scRNA-seq analysis of isolated glomerular cells from streptozotocin-induced diabetic endothelial nitric oxide synthase (eNOS)–deficient (eNOS-/-) mice and control eNOS-/- mice. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

1600 Samples

Download data: TXT

(Submitter supplied) Diabetic nephropathy (DN) is a major complication of type 1 and type 2 diabetes and may lead to kidney failure. Understanding how diabetes regulates transcriptome dynamics in DN is important for understanding the biology of the disease and for guiding development of new treatments. In this study, we identified a set of unique biomarkers and canonical pathways that may hold the key to understanding mechanisms of DN pathobiology with value for clinical translation. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

12 Samples

Download data: TXT

(Submitter supplied) diabetes, mouse models, diabetic nephropathy, streptozotocin db/db Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS887

Platform:

GPL409

50 Samples

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(Submitter supplied) Each slide contained an unbiased, random collection of 9,568 cDNA probe elements derived from the sequence-verified GEM1 clone set (Incyte Genomics Inc., Palo Alto, CA).

Organism:

Mus musculus

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Examination of kidneys from streptozotocin-induced diabetic C57BL/6J and db/db animals, which are models for type I and type II diabetes, respectively. Results identify HSD3-beta 4 and OPN as classifiers for the mesangial matrix expansion phenotype, an indicator for end-stage renal disease.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 agent, 3 disease state, 3 genotype/variation sets

Platform:

GPL409

Series:

GSE710

50 Samples

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(Submitter supplied) TGF-beta1 is the major cytokine driver of fibrotic scarring observed in diabetic nephropathy and other fibrosis-related diseases. RNA-sequencing offers the potential for more sensitive assessment of the TGF-ß1-driven transcriptome.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9052

5 Samples

Download data: TXT

(Submitter supplied) TGFbeta is the major cytokine driver of fibrosis in the kidney and other tissue. Epithelial-mesenchymal transition has been postulated to contibrute to renal fibrosis in diseases such as diabetic nephropathy. We wished to identify novel genes that were upregulated in human kidney epithelial cells in response to TGFb1.The transcriptional responses for human proximal tubule epithelial cells to 10 ng/ml TGFbeta1 was examined over 24 and 48 hr

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

9 Samples

Download data: CEL

(Submitter supplied) Comparing glomerular gene expression level between mice with different susceptibilities to diabetic nephropathy, DBA/2 (susceptible) and C57BL/6 (resistant) mice, respectively. The hypothesis is that differential expression of glomerular genes regulate susceptibility to diabetic nephropathy. The results show immune related genes. Thus, glomerular inflammation may increase susceptibility to diabetic nephropathy in mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

16 Samples

Download data: IDAT, TXT, XLSX

(Submitter supplied) We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomeruli and tubuli and was associated with increased glomerulosclerosis even in an additional set of DKD samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

25 Samples

Download data: CEL

(Submitter supplied) We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomeruli and tubuli and was associated with increased glomerulosclerosis even in an additional set of DKD samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

22 Samples

Download data: CEL

(Submitter supplied) We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomeruli and tubuli and was associated with increased glomerulosclerosis even in an additional set of DKD samples.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

22 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

69 Samples

Download data: CEL

(Submitter supplied) single-cell RNA sequencing of renal cells from type 2 diabetes mice (BTBR ob/ob) at the early stage of DN.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

16 Samples

Download data: MTX, TSV

(Submitter supplied) The pig kidney cortex tissue was collected before and after ex vivo perfusion

Organism:

Sus scrofa

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL26351

2 Samples

Download data: MTX, TSV

(Submitter supplied) To investigate the gene expression levels of major glomerular cell types in BTBR ob/ob mice and in glomeruli under hyperfiltration Bulk RNA-sequencing of glomerular cell types from BTBR ob/ob and BTBR +/+ mice at three time points (6/12/18 weeks). The glomeruli were isolated from ex vivo perfused kidney (hyperfiltration) and unperfused kidney (control) from the mouse.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24247 GPL28457

144 Samples

Download data: RESULTS

(Submitter supplied) Idiopathic nodular mesangial sclerosis, also called idiopathic nodular glomerulosclerosis (ING) is a rare clinical entity with unclear pathogenesis. The hallmark of this disease is the presence of nodular mesangial sclerosis on histology without clinical evidence of diabetes mellitus or other predisposing diagnoses. To achieve insights into its pathogenesis, we queried the clinical, histopathologic and transcriptomic features of ING and nodular diabetic nephropathy (DN)

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

32 Samples

Download data: CSV

(Submitter supplied) Treating insulin resistance with pioglitazone normalizes renal function and improves small nerve fibre function and architecture; however, it does not affect large myelinated nerve fibre function in mouse models of type 2 diabetes (T2DM), indicating that pioglitazone affects the body in a tissue-specific manner. To identify distinct molecular pathways regulating diabetic peripheral neuropathy (DPN) and nephropathy (DN), as well those affected by pioglitazone, we assessed DPN and DN gene transcript expression in control and diabetic mice with or without pioglitazone treatment. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

95 Samples

Download data: TXT