GEO DataSets

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL93

Series:

GSE1007

22 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) molecular profiles (HG-U95B,C,D,E) of biopsy skeletal muscle samples obtained from 10 normal individuals and 10 DMD patients Keywords = gene expression profiles of normal human skeletal muscles Keywords = gene expression profiles of DMD patients' skelatal muscle samples Keywords = Affymetrix HG-U95B Keywords = Affymetrix HG-U95C Keywords = Affymetrix HG-U95D Keywords = Affymetrix HG-U95E Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS609 GDS610 GDS611 GDS612

4 related Platforms

86 Samples

Download data: CEL, EXP, RPT

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL95

Series:

GSE1007

21 Samples

Download data: CEL, EXP, RPT

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL94

Series:

GSE1007

22 Samples

Download data: CEL, EXP, RPT

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from DMD patients and unaffected control patients examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL92

Series:

GSE1007

21 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Molecular profiles of dystophin-deficient patients and normal human skeletal muscles on Affymetrix HG-U95A arrays Keywords = DMD Keywords = Duchenne muscular dystrophy Keywords = dystrophin Keywords = Affymetrix U95A array Keywords = skeletal muscle Keywords = gene expression profiles Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS563

Platforms:

GPL8300 GPL91

24 Samples

Download data: CEL, EXP, RPT

Search for modifying factors and pathogenic pathways involved in Duchenne muscular dystrophy (DMD). Quadricep skeletal muscle biopsies from 12 DMD patients and 11 unaffected control patients examined.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL8300

Series:

GSE1004

23 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004. Keywords = microarray Keywords = muscle Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS638

Platform:

GPL81

36 Samples

Download data: CEL

Temporal analysis of diaphram muscle from dystrophin-deficient mdx mice, a Duchenne muscular dystrophy (DMD) model. Postnatal ages 7 to 112 days examined. Results provide insight into mechanisms of muscular dystrophy pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 6 age, 2 strain sets

Platform:

GPL81

Series:

GSE1026

36 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL9454 GPL570

65 Samples

Download data: CEL

(Submitter supplied) Primairy human myoblast cell cultures Healthy DMD Keywords: time-course

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2097

42 Samples

Download data

(Submitter supplied) Duchenne muscular dystrophy (DMD) is an X-linked genetic disease that affects 1 in 5,000 males. Skeletal muscle wasting occurs early in childhood, while cardiac involvement does not typically surface until a decade later. There is currently no method for predicting which patients will develop cardiomyopathy. The molecular reasons for the differences in timing and progression of cardiac dysfunction compared to skeletal dysfunction are unknown. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL17403

30 Samples

Download data: CEL

(Submitter supplied) Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were then treated for 3 months with oxandrolone (a synthetic anabolic steroid, 0.1 mg/kg/day) and the studies repeated. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1333 GDS1334

Platforms:

GPL96 GPL97

12 Samples

Download data

Analysis of gastrocnemius muscle biopsy specimens from Duchenne muscular dystrophy (DMD) patients before and after 3 months of treatment with 0.1mg/kg/day oxandrolone, a synthetic anabolic steroid. Results provide insight into mechanisms underlying the beneficial effect of oxandrolone in DMD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL97

Series:

GSE1764

6 Samples

Download data

Analysis of gastrocnemius muscle biopsy specimens from Duchenne muscular dystrophy (DMD) patients before and after 3 months of treatment with 0.1mg/kg/day oxandrolone, a synthetic anabolic steroid. Results provide insight into mechanisms underlying the beneficial effect of oxandrolone in DMD.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 individual sets

Platform:

GPL96

Series:

GSE1764

6 Samples

Download data

(Submitter supplied) Albeit increased serum CK level and abnormal muscle histology are always present, boys with DMD are phenotipically indistinguishable from the normal ones at birth and, in their first years of life, acquire early motor milestones at normal times. A clear defect in muscle function becomes generally apparent by the end of the second year. As the disease is typically diagnosed between the ages of 3 and 7, the first two years are often considered and referred to as clinically presymptomatic. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3027

Platform:

GPL96

37 Samples

Download data: CEL, PDF

Analysis of skeletal muscles from 1.5 to 61 month old children with Duchenne muscular dystrophy (DMD). DMD is a degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Results provide insight into the early phases of DMD pathogenesis and pathophysiology.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 22 age, 2 disease state, 2 gender sets

Platform:

GPL96

Series:

GSE6011

37 Samples

Download data: CEL

(Submitter supplied) Comparison by expression profiling of tissue from dKO (utrophin/dystrophin-deficient) and MDX mice at 8 weeks of age. Independent triplicate analyses/strain were done for extraocular, hindlimb, and cardiac muscle. Keywords = microarray Keywords = extraocular Keywords: parallel sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2001

Platform:

GPL81

18 Samples

Download data: CEL

Comparison of skeletal muscles of utrophin/dystrophin double knockout (dko) mutants and dystrophin-deficient mdx mutants. dko and mdx mutants display skeletal muscle weakness and degeneration but only dko mutants display clinical features similar to Duchenne muscular dystrophy patients.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 3 tissue sets

Platform:

GPL81

Series:

GSE1463

18 Samples

Download data: CEL

(Submitter supplied) Comparative effects of Duchenne Muscular Dystrophy (DMD) and Aging in skeletal muscle Expression profiling established by microarray technology provides a powerful tool by which complex pathways can be assembled. The pathophysiology of Duchenne Muscular Dystrophy (DMD) is a complex process involving many pathways downstream of the primary genetic insult (lack of dystrophin). Similarly, the mechanisms implicated in muscle aging are only partially understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14713

16 Samples

Download data: GPR