Similar studies for GEO DataSets (Select 4608) - GEO DataSets

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Items: 19

Select item 46081.

Analysis of trypsin-disassociated keratinocytes (KCs) isolated from normal skin as a model for epidermal injury. These sorted keratinocytes (KC sorted) were compared to KCs isolated by LCM (KC LCM) and long-term cultured KCs (KC in vitro). Results provide insight into the KC injury response.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 3 cell type, 3 protocol sets

Platform:: GPL570
Series:: GSE30355
30 Samples

Download data: CEL

DataSet

Accession:: GDS4608

ID:: 4608

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000303552.

Human keratinocytes have a response to injury that upregulates CCL20 and other genes linking innate and adaptive immunity

(Submitter supplied) In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, whether keratinocytes release molecules linked to adaptive immune responses, e.g. CCL20, in their early state of activation without signals from infiltrating T cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4608
Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE30355

ID:: 200030355

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001026413.

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

(Submitter supplied) Th subsets are defined according to their production of lineage-indicating cytokines and functions. In this study, we have identified a subset of human Th cells that infiltrates the epidermis in individuals with inflammatory skin disorders and is characterized by the secretion of IL-22 and TNF-a, but not IFN-g, IL-4, or IL-17. In analogy to the Th17 subset, cells with this cytokine profile have been named the Th22 subset. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
11 Samples

Download data: TXT

Series

Accession:: GSE102641

ID:: 200102641

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000072164.

Cytokine treated normal human epidermal keratinocytes

(Submitter supplied) Normal human epidermal keratinocytes (NHEK) from neonatal foreskin were cultured in serum-free EpiLife medium with human KC growth supplement (0.2% bovine pituitary extract (v/v), 5ug bovine insulin, 5ug/ml bovine transferrin, 0.5ng/ml human EGF, and 0.18 ug/ml hydrocortisone) from Cascade Biologics. Cultures were treated with recombinant cytokines from R&D Systems. J Immunol. 2007 Feb 15;178(4):2229-40. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2611
Platform:: GPL570
25 Samples

Download data: CEL, EXP

Series

Accession:: GSE7216

ID:: 200007216

Select item 26115.

Interleukin-20 subfamily cytokines effect on epidermal keratinocytes

Analysis of cultured epidermal keratinocytes treated with various cytokines of the interleukin-20 (IL-20) subfamily. IL-20 cytokines are up-regulated in psoriatic skin. Results provide insight into the role of IL-20 cytokines in the pathogenesis of psoriasis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 9 agent, 2 other sets

Platform:: GPL570
Series:: GSE7216
25 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2611

ID:: 2611

Select item 2001459636.

RNA-seq of mouse primary keratinocytes treated with recombinant IL-33

(Submitter supplied) Mouse primary keratinocytes were treated with recombinant IL-33 to elucidate the effect of IL-33 signaling on keratinocytes

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
6 Samples

Download data: TXT

Series

Accession:: GSE145963

ID:: 200145963

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000202647.

Transcriptome of inflammatory myeloid DCs in psoriasis

(Submitter supplied) Background: Previous work has identified CD11c+CD1c- dendritic cells (DCs) as the major ”inflammatory” dermal DC population in psoriasis vulgaris and CD1c+ DCs as the “resident” cutaneous DC population. Objective: To further define molecular differences between these two myeloid dermal DC populations. Methods: Inflammatory and resident DCs were single-cell sorted from psoriasis lesional skin biopsies, and gene array expression profiling was performed. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
7 Samples

Download data: CEL

Series

Accession:: GSE20264

ID:: 200020264

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001453058.

Combined miRNA-mRNA transcriptional profiling in the human skin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL17586 GPL19117
14 Samples

Download data: CEL

Series

Accession:: GSE145305

ID:: 200145305

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001453049.

Combined miRNA-mRNA transcriptional profiling in the human skin [mRNA_PSOR]

(Submitter supplied) mRNA and miRNA transcription changes during epidermal differentiation and between lesional psoriatic skin and normal skin were analysed

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
6 Samples

Download data: CEL

Series

Accession:: GSE145304

ID:: 200145304

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014505910.

Combined miRNA-mRNA transcriptional profiling in the human skin [Kera]

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array; Expression profiling by array

Platforms:: GPL16686 GPL19117
18 Samples

Download data: CEL

Series

Accession:: GSE145059

ID:: 200145059

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014505811.

Combined miRNA-mRNA transcriptional profiling in the human skin [mRNA_Kera]

(Submitter supplied) mRNA and miRNA transcription changes during epidermal differentiation were analysed using proliferating keratinoctes (pKC), differentiated keratinocytes (dKC) and skin equivalents (SE)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
9 Samples

Download data: CEL

Series

Accession:: GSE145058

ID:: 200145058

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014505612.

Combined miRNA-mRNA transcriptional profiling in the human skin [miRNA_Kera]

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL19117
9 Samples

Download data: CEL

Series

Accession:: GSE145056

ID:: 200145056

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014505413.

Combined miRNA-mRNA transcriptional profiling in the human skin [miRNA_PSOR]

(Submitter supplied) mRNA and miRNA transcription changes during epidermal differentiation and between lesional psoriatic skin and normal skin were analyzed

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL19117
8 Samples

Download data: CEL

Series

Accession:: GSE145054

ID:: 200145054

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010918214.

RNA-seq analysis of IL-1B and IL-36 responses in epidermal keratinocytes identifies a shared MyD88-dependent gene signature

(Submitter supplied) IL-36 cytokines have recently emerged as mediators of inflammation in autoimmune conditions including psoriasis vulgaris (PsV) and generalized pustular psoriasis (GPP). This study used RNA-seq to profile the transcriptome of primary epidermal keratinocytes (KCs) treated with IL-1B, IL-36A, IL-36B or IL-36G. We identified some early IL-1B-specific responses (8 hours post-treatment), but nearly all late IL-1B responses were replicated by IL-36 cytokines (24 hours post-treatment). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10999
34 Samples

Download data: TXT

Series

Accession:: GSE109182

ID:: 200109182

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20002476715.

Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis

(Submitter supplied) We sought to provide a comprehensive evaluation of the effects of TNF-α and IL-17 on the keratinocyte gene profile in order to identify genes that might be co-regulated by these cytokines. We then sought to determine how genes that were synergistically activated by both cytokines relate to the psoriasis transcriptome. Here, we identified 160 unique genes that were synergistically up-regulated by IL-17 and TNF-α and 188 unique genes where the two cytokines had at least an additive effect. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
22 Samples

Download data: TXT

Series

Accession:: GSE24767

ID:: 200024767

Select item 20005059816.

AMPK epidermal inhibition promotes HuR cytoplasmic localization eliciting post-transcriptional inflammatory response in psoriasis

(Submitter supplied) IL-20 cytokines are involved in the establishment of psoriasis, a common chronic skin inflammation epidemiologically associated with metabolic syndrome, but molecular mechanisms underlying their over-expression remain to be elucidated. We find that keratinocytes (KCs) expressed IL-20 and lymphocytes expressed IL-22 cytokines up-regulation occurs at post-transcriptional level with stabilization of their RNA messengers. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
3 Samples

Download data: TXT

Series

Accession:: GSE50598

ID:: 200050598

Select item 20000660117.

High Expression Levels of Keratinocyte Antimicrobial Proteins in Psoriasis Compared with Atopic Dermatitis.

(Submitter supplied) Recently, it was shown that lesional skin of atopic dermatitis patients expresses low levels of some antimicrobial peptides, compared with psoriasis patients. Here we performed microarray analysis on mRNA from purified lesional epidermal cells of patients with chronic plaque psoriasis and chronic atopic dermatitis, to investigate whether this is a general phenomenon for host defense proteins, and how specific it is for this class of molecules. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4695
6 Samples

Download data: GPR, TIFF

Series

Accession:: GSE6601

ID:: 200006601

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003638718.

PSORS2 is due to mutations in CARD14

(Submitter supplied) Psoriasis is a common, immune-mediated, genetic disorder of the skin associated with arthritis in approximately 30% of cases. Previously, we localized PSORS2 (psoriasis susceptibility locus 2) to chromosome 17q25.3-qter following a genome-wide linkage scan in a family of European origin with multiple cases of psoriasis and psoriatic arthritis. Linkage to PSORS2 was also observed in a multiply affected psoriasis family from Taiwan. more...