GEO DataSets

Analysis of liver from medium-chain acyl-coenzyme A dehydrogenase-deficient (MCAD-/-) adult males during fasting and during an LPS-induced acute phase response. Results provide insight into the molecular basis of disturbed hepatic carbohydrate management during metabolic stress in MCAD-/- mutants.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:

GPL1261

Series:

GSE37546

20 Samples

Download data: CEL

(Submitter supplied) Medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCAD) catalyzes crucial steps in mitochondrial fatty acid oxidation, a process that is of key relevance for maintenance of energy homeostasis, especially during high metabolic demand. To gain insight into the metabolic consequences of MCAD deficiency under these conditions, we compared hepatic carbohydrate metabolism in vivo in wild-type and MCAD-/- mice during fasting and during a lipopolysaccharide (LPS)-induced acute phase response (APR). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4546

Platform:

GPL1261

20 Samples

Download data: CEL

(Submitter supplied) During fasting, mitochondrial fatty-acid β-oxidation (mFAO) is essential for the generation of glucose by the liver. Children with a loss-of-function deficiency in the mFAO enzyme medium-chain acyl-Coenzyme A dehydrogenase (MCAD) are at serious risk of life-threatening low blood glucose levels during fasting in combination with intercurrent disease. However, a subset of these children remains asymptomatic throughout life. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

32 Samples

Download data: TXT

(Submitter supplied) Background In the postabsorptive state, the portal-drained viscera are a major energy consumer, but a comprehensive overview of the adaptive fasting response in the liver is lacking. Hence, gene-expression profiling, pathway, network and gene-set enrichment analysis and immunohistochemistry were carried out on mouse liver after 0, 12, 24, and 72 hours of fasting. Results Liver weight has fallen to 50% of control after three days of fasting, hepatocyte size was reduced with no apparent increase in apoptosis, while the basic liver structure and metabolic zonnation were preserved. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3642

Platform:

GPL922

12 Samples

Download data: TIFF, TXT

Analysis of livers from male FVB animals fasting for up to 72 hours. Results provide insight into the adaptive response of the liver to fasting.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 4 time sets

Platform:

GPL922

Series:

GSE10653

12 Samples

Download data: TIFF, TXT

(Submitter supplied) Tumor-associated macrophages (TAMs) are increasingly viewed as a target of great relevance in the tumor microenvironment, because of their important role in cancer progression and metastasis. However, the endogenous regulatory mechanisms underlying TAM differentiation remain largely unknown. Here, we report that caspase-1 promotes TAM differentiation by cleaving peroxisome proliferator-activated receptor gamma (PPARγ) at Asp64, thus generating a 41 kDa fragment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

9 Samples

Download data: CEL

(Submitter supplied) How signals from fatty acid metabolism are translated into changes in food intake remains unclear. Previously we reported that mice with a genetic inactivation of Acads (short-chain acyl-CoA dehydrogenase), encoding the enzyme responsible for mitochondrial beta-oxidation of C4-C6 short-chain fatty acids (SCFAs), shift consumption away from fat and toward carbohydrate when offered a choice. This finding demonstrated that the loss of a specific enzyme in fatty acid oxidation alters the choice of diet intake. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2995

24 Samples

Download data: TXT

(Submitter supplied) Background The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting. Results Intestinal weight declined to 50% of control, but this loss of tissue mass was distributed proportionally among the gut’s structural components, so that the microarrays’ tissue base remained unaffected. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL922

12 Samples

Download data: TIFF, TXT