GEO DataSets

Analysis of striatum and cerebellum from alpha-synuclein (SNCA) knockouts at 6 or 21 months of age. SNCA mutations result in impaired movement and depression/anxiety, manifesting in humans as Parkinson's disease (PD). Results provide molecular insights into physiological role of alpha-synuclein.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 time, 2 tissue sets

Platform:

GPL1261

Series:

GSE19534

26 Samples

Download data: CEL

(Submitter supplied) Alpha-synuclein is an abundant protein implicated in synaptic function and plasticity, but the molecular mechanism of its action is not understood. Missense mutations and gene duplication/triplication events result in Parkinson's disease, a neurodegenerative disorder of old age with impaired movement and emotion control. Here, we systematically investigated the striatal as well as the cerebellar transcriptome profile of alpha-synuclein-deficient mice via a genome-wide microarray survey in order to gain hypothesis-free molecular insights into the physiological function of alpha-synuclein. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4153

Platform:

GPL1261

26 Samples

Download data: CEL

(Submitter supplied) The pre-synaptic protein α-synuclein is a key player in the pathogenesis of Parkinson's disease. Together with accumulation and missfolding of α-synuclein protofibrils serve as seed structures for the aggregation of numerous proteins in the cytoplasm of neuronal cells, the so-called Lewy bodies. Furthermore, missense mutations in the SNCA gene and gene multiplications lead to autosomal dominant forms of familiar PD. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL, CHP

(Submitter supplied) Genetic perturbations of the transcription factor, Forkhead Box P1 (FOXP1), occur in patients with autism spectrum disorder who have an increased risk for comorbidity with intellectual disability. Recent work has begun to reveal an important role for Foxp1 in brain development, but the brain region-specific contribution of Foxp1 to autism and intellectual disability phenotypes has yet to be fully determined. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

16 Samples

Download data: XLS

(Submitter supplied) Foxp1 was strongly expressed in developing lens, and its knockout in lens resulted in failure of appropriate lens development. By microarray analysis, we examined effects of loss-of Foxp1 for gene expression pattern of lens at P0 developmental stage.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

2 Samples

Download data: TXT, XLSX

(Submitter supplied) Mutations in the gene encoding the transcription factor forkhead box P1 or FOXP1 occur in patients with neurodevelopmental disorders, including autism. However, the function of FOXP1 in the brain remains mostly unknown. Here, we identify the gene expression program regulated by FoxP1 in both human neural cells and mouse brain and demonstrate a conserved role for FOXP1 transcriptional regulation of autism and Fragile X Mental Retardation Protein (FMRP) mediated pathways. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL11154 GPL13112

36 Samples

Download data: BED, TXT

(Submitter supplied) Examination of 2 different developmental time points (P0 and P7) in the cortex of control and Foxp1 cKO mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23479 GPL19057

16 Samples

Download data: XLSX

(Submitter supplied) Methylglyoxal (MG) is a reactive alpha-dicarbonyl by-product of glycolysis. Several bio-defense systems to detoxify the highly toxic MG are equipped in our body, including an enzymatic system by glyoxalase (GLO) 1 and GLO2 and a scavenge system by vitamin B6 (VB6). We have reported that some population of patients with schizophrenia shows impairment of the MG detoxification systems. Although we have evidences showing a link between impairment of MG detoxification systems and development of schizophrenia, the molecular mechanism to connect them remains poorly understood. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

60 Samples

Download data: TXT

(Submitter supplied) We generated mice with a transgenic BAC on a B6 background. The BAC contains Glo1, and the transgenic mice were found to overexpress Glo1. We performed a microarray on whole-brain RNA of adult mice to identify differentially expressed genes resulting from Glo1 overexpression.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4991

Platform:

GPL6246

10 Samples

Download data: CEL

Analysis of brains from C57BL/6J transgenics overexpressing glyoxalase 1 (Glo1). Glo1 is a cytosolic enzyme that catabolizes acyclic alpha-oxoaldehydes, particularly methylglyoxal. Results provide insight into the effect of Glo1 on anxiety-like behavior.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL6246

Series:

GSE36819

10 Samples

Download data: CEL