GEO DataSets

Analysis of placentas of women who smoked during pregnancy. Smoking increases the risk of preterm delivery and complications such as placental previa and abruption. Results provide insight into the molecular basis of smoke-induced placental abnormalities.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 dose sets

Platform:

GPL6104

Series:

GSE18044

76 Samples

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(Submitter supplied) Smoking in pregnancy increases a woman's risk of preterm delivery resulting in serious health problems during the newborn period, chronic lifelong disabilities (such as cerebral palsy, mental retardation and learning problems), and even death. Further, smoking women have placental problems such as placenta previa (a low-lying placenta that covers part or all of the opening of the uterus), placental abruption (in which the placenta peels away, partially or almost completely before delivery) often resulting in bleeding during delivery. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3793

Platform:

GPL6104

76 Samples

Download data: TXT

(Submitter supplied) Maternal smoking has a severe negative effect on all stages of pregnancy that in consequence impairs fetal growth and development. Tobacco smoke-related defects are well established at the clinical level; however, little is known about molecular mechanisms underlying these pathological conditions. We thus employed a genomic approach to determine transcriptome alterations induced by maternal smoking in pregnancy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3929

Platform:

GPL6883

183 Samples

Download data: TXT

Analysis of peripheral blood leukocytes and placenta of pregnant smokers. Umbilical cord blood leukocytes of their newborns also examined. Maternal smoking has a negative effect on all stages of pregnancy. Results provide insight into molecular mechanisms underlying tobacco smoke-related defects.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 3 specimen sets

Platform:

GPL6883

Series:

GSE27272

183 Samples

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(Submitter supplied) Passive smoke intake by pregnant women may have detrimental effects such as spontaneous abortion, lower birth weight, stillbirth, and reduced infant lung function. To extend our knowledge on molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them to those in active smokers (AS). Using Illumina Expression Beadchip with 24,526 transcript probes, gene expression patterns were assayed in placentas from PS (N=25) exposed to environmental tobacco smoke (ETS) throughout pregnancy and non-exposed (NS) counterparts (N=35), and in cord blood cells from their newborns. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6883

104 Samples

Download data: TXT

(Submitter supplied) Although a number of animal model studies have addressed changes in gene expression in the parenchyma and their relationship to emphysema, much less is known about the pathogenesis of cigarette smoke-induced small airway remodeling. In this study, we exposed rat tracheal explants to whole smoke for 15 minutes, and then cultured the explants in air. The airway transcriptome was evaluated using RAE 230_2 GeneChips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3746

Platform:

GPL1355

47 Samples

Download data: CEL

Analysis of tracheal explants at 2hrs and 24hrs following brief exposure to whole smoke. Some of the explants were pretreated with dexamethasone prior to smoke exposure. Results provide insight into the molecular mechanisms underlying pathogenesis of cigarette smoke-induced small airway remodeling.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 stress, 2 time sets

Platform:

GPL1355

Series:

GSE15563

47 Samples

Download data: CEL

(Submitter supplied) Gene expression in placenta from 5 smoking and 5 non-smoking mothers analyzed by Affymetrix Hg133_plus2 microarrays. Keywords: Toxic response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2990

Platform:

GPL570

10 Samples

Download data: CEL

Analysis of full-term placentas exposed to maternal cigarette smoke. The placenta produces and metabolizes steroids and xenobiotics. Results provide insight into the effects of maternal cigarette smoking on the placenta at term, with a focus on xenobiotic- and steroid-metabolizing genes.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 gender, 2 stress sets

Platform:

GPL570

Series:

GSE7434

10 Samples

Download data: CEL

(Submitter supplied) Maternal smoking doubles the risk of delivering a low birth weight infant. The purpose of this study was to analyze differential gene expression in umbilical cord tissue as a function of maternal smoking, with an emphasis on growth-related genes. We recruited 15 pregnant smokers and 15 women who never smoked during pregnancy to participate RNA was isolated from umbilical cord tissue collected and snap frozen at the time of delivery. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

30 Samples

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(Submitter supplied) 40 current smokers and 40 age- and gender- matched never smokers underwent buccal biopsies.The study had four objectives: (a) to define the effects of smoking on the transcriptome of oral epithelial cells; (b) to determine if any of the effects of tobacco smoke on the transcriptome are gender-dependent; (c) to compare the effects of tobacco smoke exposure on the transcriptome in oral v. bronchial epithelium and (d) to identify agents with the potential to suppress the effects of tobacco smoke on the transcriptome. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3709

Platform:

GPL570

79 Samples

Download data: CEL

Analysis of oral mucosae from 40 cigarette smokers and 40 age and gender matched never-smokers. Results provide insight into the carcinogenic effects of cigarette smoke.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 gender sets

Platform:

GPL570

Series:

GSE17913

79 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; synthetic construct

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL17400 GPL16384

45 Samples

Download data: CEL

(Submitter supplied) Background: In utero smoke exposure is a recognized risk factor for impaired lung function development and a significant risk factor for airway disease. Despite intensive anti-tobacco campaigns the prevalence of smoking pregnant women has remained high requiring additional strategies to protect the offspring’s lung. To achieve this goal, it is critical to understand the mechanisms how disease risks are established in early life. more...

Organism:

synthetic construct; Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL16384

24 Samples

Download data: CEL

(Submitter supplied) Background: In utero smoke exposure is a recognized risk factor for impaired lung function development and a significant risk factor for airway disease. Despite intensive anti-tobacco campaigns the prevalence of smoking pregnant women has remained high requiring additional strategies to protect the offspring’s lung. To achieve this goal, it is critical to understand the mechanisms how disease risks are established in early life. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17400

21 Samples

Download data: CEL

(Submitter supplied) Cigarette smoke components have a proven negative influence on human health. Adverse metabolic effects have been observed in tissues and single cells. As T-lymphocytes get in contact with affected organs (e.g. lung) or cells (e.g.erythrocytes), as well as with smoke components and bioactive molecules, whose production is influenced by them, we compared the gene exression profiles in these cells of the adaptive immune system of three male heavy smokers and three male non-smokers We combined rapid immuno-precipitation and Affymetrix GeneChip® HG U133A2.0 microarray analysis to analyse the data set. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2563

Platform:

GPL571

6 Samples

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Analysis of T lymphocytes of 3 male heavy smokers. Results provide insight into sensitivity of T lymphocytes to cigarette smoking.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 specimen sets

Platform:

GPL571

Series:

GSE4806

5 Samples

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