Similar studies for GEO DataSets (Select 3367) - GEO DataSets

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Items: 2

Select item 33671.

Argyrin A effect on MCF7 breast cancer cells: time course

Temporal analysis of MCF7 breast adenocarcinoma cells treated with argyrin A, a proteasome inhibitor that induces apoptosis by stabilizing cyclin kinase inhibitor p27kip1. Results provide insight into the molecular mechanisms that make argyrin A-induced cell death dependent upon p27kip1 expression.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 agent, 5 time sets

Platform:: GPL570
Series:: GSE8565
17 Samples

Download data: CEL

DataSet

Accession:: GDS3367

ID:: 3367

Select item 2000085652.

Argyrin A is a p27 stabilizing drug with potent antiproliferative activity in vivo

(Submitter supplied) Reduction in the cellular levels of the cyclin kinase inhibitor p27kip1 are frequently found in many human cancers and correlate directly with patient prognosis. Specifically ubiquitin dependent proteasomal turnover has been shown to cause reduced p27 expression in many human cancers. We recently demonstated that expression of a stabilized version of p27kip1 (p27kip1T187A) in a genetically modified mouse significantly reduced the number of intestinal adenomatous polyps which progressed to invasive carcinomas. more...