GEO DataSets

Analysis of primary culture tracheal epithelial cells following infection with Sendai virus (SeV), a common paramyxovirus.Respiratory paramyxoviral infections are a leading cause of serious respiratory disease. Results provide insight into the role of epithelial cells in antiviral defense.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 infection sets

Platform:

GPL81

Series:

GSE10211

10 Samples

Download data: CEL

(Submitter supplied) Oligonucleotide microarrays were used to establish a profile for gene expression in wild-type airway epithelial cells after paramyxoviral infection. Analysis was performed on mRNA isolated from SeV-infected primary-culture mouse tracheal epithelial cells that were maintained under physiologic conditions (air-liquid interface). Keywords: Treatment Comparison

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3210

Platform:

GPL81

10 Samples

Download data: CEL

(Submitter supplied) Sendai virus is a potent inducer of type I interferons in human cells. Type I interferons consist of 13 different IFN alpha genes and 1 IFN beta gene. Each of these subtypes have differing functional activites depending on the infecting virus and cell. However, the exact signaling pathways that lead to the induction of individual type I IFN subtypes are not known. We have found that inefction with 2 different concentrations of Sendai virus in the human monocytoid cell line U937 results in 2 distinct profiles of type I IFN subtypes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS6082

Platform:

GPL10558

11 Samples

Download data: TXT

Analysis of U937 monocytic cells infected at multiplicities of infection of 0.0002 and 0.02 with the Sendai virus. Results provide insight into the differences between the innate immune response of cells infected with a low and high concentration of virus.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 dose, 2 infection sets

Platform:

GPL10558

Series:

GSE67198

11 Samples

Download data

(Submitter supplied) Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

12 Samples

Download data: TXT

(Submitter supplied) Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

12 Samples

Download data: TXT

(Submitter supplied) Rhinovirus infections exacerbate chronic respiratory inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Airway epithelial cells are the primary site of rhinovirus replication and responsible for initiating the host immune response to infection. Numerous studies have reported that the anti-viral innate immune response in asthma is deficient leading to the conclusion that epithelial innate immunity is a key determinant of disease severity during a rhinovirus induced exacerbation. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

120 Samples

Download data: CSV

(Submitter supplied) The objective of this study was to compare the ability of mice that lack STAT1 to resolve a neurotropic viral challenge, and to assess the ability of neurons obtained from these mice to be effectively cleared of virus by interferon gamma

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

23 Samples

Download data: TXT

(Submitter supplied) Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Keywords: disease state analysis

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL1261 GPL339

18 Samples

Download data: CEL

(Submitter supplied) Analysis of normal human tracheobronchial epithelial cells treated with or without recombinant human GDF15 for two hours. Results provide insights of the genome-wide transcriptional regulation by Smad1 associated with GDF15 in human airway epithelium.

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17303

4 Samples

Download data: BED

(Submitter supplied) The mechanisms by which pulmonary lesions and fibrosis are generated during SARS-CoV infection are not known. Using high-throughput mRNA profiling, we examined the transcriptional response of wild-type (WT), type I interferon receptor knockout (IFNAR1−/−), and STAT1 knockout (STAT1−/−) mice infected with a recombinant mouse-adapted SARS-CoV (rMA15) to better understand the contribution of specific gene expression changes to disease progression.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

36 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

12 Samples

Download data: TXT

(Submitter supplied) To investigate the contribution of type I interferon to neutrophil adaptation to the lung during ARDS and COVID-induced ARDS.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

6 Samples

Download data: TXT

(Submitter supplied) To investigate neutrophil adaptation to the lung during ARDS and COVID-induced ARDS.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

6 Samples

Download data: TXT