GEO DataSets

Analysis of skeletal muscles of postmenopausal women treated with hormone replacement therapy (HRT) or with a placebo. Menopause is accompanied by age-associated changes in muscle structure and function. Results provide insight into the effect of HRT and estrogen deprivation on skeletal muscles.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 15 individual, 2 other, 2 protocol sets

Platform:

GPL2700

Series:

GSE6348

30 Samples

Download data

(Submitter supplied) Modification of Gene Expression of Skeletal Muscle in Response to postmenopause with or without Hormone Replacement Therapy. Test samples randomly selected from a larger study in order to verify the validity of microarray experiment. Keywords: time course analysis from HRT users and non-users

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4590

5 Samples

Download data: TXT

(Submitter supplied) Modification of Gene Expression of Skeletal Muscle in Response to postmenopause with or without Hormone Replacement Therapy. Even though menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3100

Platform:

GPL2700

30 Samples

Download data: TXT

(Submitter supplied) Analysis of gene expression profiles in skeletal muscle tissue after long-term use of HRT. Networks of enriched processes in skeletal muscle responding to long-term use of estrogen-based HRT in comparison with women without any HRT in a genetically controlled setting were contructed. The association between the expression of specific biological processes and muscle composition or performance was tested. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3855

Platform:

GPL6884

22 Samples

Download data: TXT

Analysis of skeletal muscle biopsies from monozygotic female twin pairs (55-62 years) discordant for estrogen-based, HRT (2-16 years). Results provide insight into molecular mechanisms underlying the beneficial effects of long-term HRT on skeletal muscle characteristics.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6884

Series:

GSE21421

22 Samples

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(Submitter supplied) Muscle mass and strength reduce during ageing with a steeper decline in women around the age of 50, which suggests that the menopausal transition is one of the mechanisms for age-induced neuromuscular deteriorations. At the moment, there is no clear explanation for the decline in muscle properties although both physical exercise and maintaining near premenopausal estrogen levels by hormonal replacement have been helpful in their preservation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2700 GPL2507

60 Samples

Download data: TXT

(Submitter supplied) We used gene microarray analysis to compare the global expression profile of genes involved in adaptation to exercise training in skeletal muscle from chronically strength/resistance trained (ST), endurance trained (ET) and untrained control subjects (Con). Resting skeletal muscle samples (~100mg) were obtained from the vastus lateralis of 20 subjects (Con n=7, ET n=7, ST n=6; trained groups >8 years specific training). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6042

21 Samples

Download data: GPR

(Submitter supplied) Although studies have established that exogenous growth hormone (GH) treatment stimulates growth in fish, its effects on target tissue gene expression are not well characterized. We assessed the effects Posilac® (Monsanto Co., St. Louis, MO), a recombinant bovine somatotropin, on tissue transcript levels. Transcript abundance was measure in liver and muscle using the GRASP 16 K cDNA microarray. A selection of the genes identified as altered with the microarray, and also transcripts for insulin-like growth factors, growth hormone receptors (GHR) and myostatins were measured by realtime PCR in the liver, muscle, brain, kidney, intestine, stomach, gill and heart. more...

Organism:

Oncorhynchus mykiss; Salmo salar

Type:

Expression profiling by array

Platform:

GPL3976

16 Samples

Download data: TXT

(Submitter supplied) a genomic profile of aged rat sceletal muscle with diffrent degrees of sensorimotor disturbances. Keywords: age skeletal muscle sensorimotor disturbances

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1921

9 Samples

Download data: GPR

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) In this study we have identified the target genes of SREBP1a and SREBP1c in primary cultures of human skeletal muscle cells using adenoviral vectors expressing the mature nuclear form of human SREBP1a or SREBP1c combined with oligonucleotide microarrays. Keywords: comparison of human myotubes infected either by SREBP1a or 1C

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1456

6 Samples

Download data: GPR

(Submitter supplied) The American Women’s Health Initiative study published in July 2002 caused considerable concern among hormone replacement therapy (HRT) users and prescribers in many countries. This study is an exploratory research comparing the genome wide expression profile in whole blood samples according to HRT use. Within the Norwegian Women and Cancer study, 100 postmenopausal women (50 HRT users and 50 non-HRT users) born between 1943 and 1949 with normal to high body mass index and no other medication use were selected. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1412

Platform:

GPL887

89 Samples

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Comparison of whole blood samples from 42 postmenopausal women on hormone replacement therapy (HRT) to those of 47 postmenopausal women not on HRT. Subjects are part of the Norwegian Women and Cancer Study (NOWAC).

Organism:

Homo sapiens

Type:

Expression profiling by array, log10 ratio, 2 protocol sets

Platform:

GPL887

Series:

GSE3492

89 Samples

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(Submitter supplied) The aim of this investigation was to develop a global view of muscle transcriptional differences between older men and women and with aging for each sex.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4858

Platform:

GPL570

22 Samples

Download data: CEL

Analysis of biceps brachii muscles from men and women 19 to 28 or 65 to 76 years of age. Results provide insight into the influence of gender on age-related changes in the molecular properties of the skeletal muscle.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 age, 2 gender sets

Platform:

GPL570

Series:

GSE38718

22 Samples

Download data: CEL