Similar studies for GEO DataSets (Select 2734) - GEO DataSets

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Items: 20

Select item 27341.

DNA-associated protein Stonewall deficiency effect on ovaries

Comparison of ovaries from bag of marbles (bam) mutants and stonewall (stwl) bam double mutants. Stwl is a DNA-associated protein required for germline stem cell (GSC) maintenance; Bam is a key differentiation factor. Results provide insight into the role of Stwl in maintaining germ cell identity.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1322
Series:: GSE6928
6 Samples

Download data: CEL

DataSet

Accession:: GDS2734

ID:: 2734

Select item 2000069282.

Stonewalling Drosophila stem cell differentiation by epigenetic controls

(Submitter supplied) Abstract: During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely by preventing the expression of factors that promote differentiation. This is accomplished via the activity of several genes acting either in the GSC or its niche. The translational repressors, Nanos and Pumilio, act in GSCs to prevent differentiation, likely by inhibiting translation of early differentiation factors, while niche signals prevent differentiation by silencing transcription of the differentiation factor Bam. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS2734
Platform:: GPL1322
6 Samples

Download data: CEL

Series

Accession:: GSE6928

ID:: 200006928

Select item 2000659323.

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and snf[148] ovary Transcriptomes

(Submitter supplied) Comparison of wild type and tumorous ovaries reveals that tumors inappropriately express a large number of testis genes

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
4 Samples

Download data: TXT

Series

Accession:: GSE65932

ID:: 200065932

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000967514.

Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms

(Submitter supplied) Purpose: Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through piRNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear if it plays any roles in early GSC lineage development. Results: The study reveals a novel function of Aub in GSCs and their progeny, which promotes translation of self-renewal and differentiation factors by directly binding to its target mRNAs and interacting with translational initiation factors.

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL17275
3 Samples

Download data: BED

Series

Accession:: GSE96751

ID:: 200096751

PubMed Similar studies SRA Run Selector

Select item 2002299435.

Chromatin and gene expression changes during female Drosophila germline stem cell development.

(Submitter supplied) The maintenance and differentiation of highly potent animal stem cells generates an epigenetic cycle that underlies development. Drosophila female germline stem cells (GSC) produce cystoblast daughters that differentiate into nurse cells and oocytes. Developmental chromatin analysis profiling the differentiation of GSCs into cystoblasts and NCs of increasing ploidy shows that cystoblasts start developing by forming heterochromatin while in a transient syncytial state, the germline cyst, reminiscent of early embryonic cells. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis

Platform:: GPL19132
28 Samples

Download data: BEDGRAPH, BW, CSV, TXT

Series

Accession:: GSE229943

ID:: 200229943

PubMed Full text in PMC Similar studies

Select item 2001428306.

microRNA expression analysis in fly ovaries from wuho and mei-p26 mutants

(Submitter supplied) Purpose: The goal of this study is to analyze microRNA affected by wuho and mei-p26 mutations in Drosophila ovary Ovarian microRNA prolife of 7 day old control flies and flies bearing wuho and mei-p26 mutations, in duplicate.Sample libraries were prepared using the QIAseq miRNA Library Kit (QIAGEN) according to the manufacturer's protocols. Adaptors are ligated sequentially to the 3' and 5' ends of miRNAs. more...

Organism:: Drosophila melanogaster

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19132
6 Samples

Download data: XLSX

Series

Accession:: GSE142830

ID:: 200142830

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001428297.

Gene expression analysis in fly ovaries from wuho mutant

(Submitter supplied) Purpose: The goal of this study is to analyze genes affected by wuho mutation in Drosophila ovary Ovarian mRNA prolife of 7 day old control flies and flies bearing wuho mutation, in duplicate, using Illumina NextSeq 500. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
4 Samples

Download data: XLSX

Series

Accession:: GSE142829

ID:: 200142829

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000780808.

Expression data from bam and setdb1 mutant ovaries

(Submitter supplied) Germline stem cell self-renewal and differentiation are required for sustained production of gamates. GSC differentiation in drosophila requires expression of setdb1 by the somatic niche, however its function is not known. We used microarray analysis to determine what genes does setdb1 regulate to affect differentiation.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE78080

ID:: 200078080

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000226869.

Expression analysis of laser cut germaria vs laser cut apex of testes

(Submitter supplied) Here we used laser cutting microdissection and RNA amplification to profile the gene expression in wildtype female germaria and male apex of the testes. These tissue contain germline stem cells and early dividing germ cells. Our goal was to identify genes expressed in these cell types.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL3880
4 Samples

Download data: GPR

Series

Accession:: GSE22686

ID:: 200022686

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009382810.

E(Pc) ChIP-seq experiment in fruitfly testis somatic gonadal cells and RNA-seq experiment in fruitfly testis

(Submitter supplied) With the ChIP-seq experiment, we identified direct target genes of E(Pc) specifically in somatic gonadal cells. We found that the E(Pc)-binding genes are enriched with signaling pathway components, consistent with our functional data showing prevailing germline defects even when E(Pc) function is exclusively compromised in somatic gonadal cells. In addition, we also performed RNA-seq to compare transcriptomes between E(Pc) knockdown testes and control testes.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16479 GPL17275
8 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE93828

ID:: 200093828

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009530911.

Gene expression analyses in otefin mutant Drosophila ovaries

(Submitter supplied) LEM Domain proteins are key components of the nuclear lamina. Mutations in LEM-D proteins cause dystrophic diseases associated with compromised adult stem cells, yet it remains unclear how LEM-D proteins support stem cell function. Studies described here use the homologue of the LEM-D protein emerin in Drosophila, Otefin (Ote) as a model to understand LEM-D protein function in adult stem cells. Loss of Ote causes female sterility due to a complex germline stem cell (GSC) phenotype that includes both an early block in germline differentiation followed by GSC death. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
8 Samples

Download data: CEL

Series

Accession:: GSE95309

ID:: 200095309

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000278412.

GSC differentiation-reversion test

(Submitter supplied) gene expression is tested for an association with GSCs by comparing expression levels in ovary tips of c587-GAL4; hs-bam UAS-dpp females at 0 hr, 20 hr and 50 hr after heat shock ; results of two independent experiments are given as expt 1 and expt 2 Keywords: time course, heat shock, bam overexpression

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS1906
Platform:: GPL72
6 Samples

Download data

Series

Accession:: GSE2784

ID:: 200002784

Select item 20000278313.

GSC vs Kc

(Submitter supplied) This series compares gene expression between germ line stem cells (GSCs) purified either from bam mutant or Dpp-overexpressing ovaries, with gene expression in Kc cells Keywords: bam mutant, Dpp overexpression

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS1905
Platform:: GPL72
9 Samples

Download data

Series

Accession:: GSE2783

ID:: 200002783

Select item 190614.

Ovarian germ line stem cell differentiation and reversion: time course

Analysis of Dpp expanded germ line stem cells (GSCs) at various time points up to 50 hours following transient bam gene induction. GSCs differentiate into cystocytes 20 hours following bam induction. Cystocytes revert to GSCs 30 hours later. Results identify candidate GSC-specific genes.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 cell type, 2 protocol, 3 time sets

Platform:: GPL72
Series:: GSE2784
6 Samples

Download data

DataSet

Accession:: GDS1906

ID:: 1906

Select item 190515.

Ovarian germ line stem cells expanded by Dpp overexpression and bam mutation

Analysis of purified ovarian germ line stem cells (GSCs) expanded by overexpression of the bone morphogenetic protein Dpp or by mutating the bam gene. Kc tissue culture cells also examined. Dpp represses bam transcription. Results provide insight into the mechanisms of GSC maintenance and function.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 cell type, 3 genotype/variation sets

Platform:: GPL72
Series:: GSE2783
9 Samples

Download data

DataSet

Accession:: GDS1905

ID:: 1905

Select item 20011932816.

Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in female Drosophila

(Submitter supplied) Germline stem cells (GSCs) self-renew and differentiate to sustain a continuous production of gametes. In the female Drosophila germ line, two differentiation factors, bag of marbles (bam) and benign gonial cell neoplasm (bgcn), work in concert in the stem cell daughter to promote the generation of eggs. In GSCs, bam transcription is repressed by signaling from the niche and is activated in stem cell daughters. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
4 Samples

Download data: TXT

Series

Accession:: GSE119328

ID:: 200119328

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007447617.

Translational control of autophagy by Orb in the Drosophila germline

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL5112
12 Samples

Download data: TXT

Series

Accession:: GSE74476

ID:: 200074476

Select item 20007447518.

Translational control of autophagy by Orb in the Drosophila germline [mature]

(Submitter supplied) Drosophila Orb, the homologue of vertebrate CPEB is a key translational regulator involved in oocyte polarity and maturation through poly(A) tail elongation of specific mRNAs. orb has also an essential function during early oogenesis which has not been addressed at the molecular level. Here, we show that orb prevents cell death during early oogenesis, thus allowing oogenesis to progress. It does so through the repression of autophagy, by directly repressing, together with the CCR4 deadenylase, the translation of Autophagy-specific gene 12 (Atg12) mRNA. more...

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL5112
6 Samples

Download data: TXT

Series

Accession:: GSE74475

ID:: 200074475

Select item 20007447419.

Translational control of autophagy by Orb in the Drosophila germline [early]

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL5112
6 Samples

Download data: TXT

Series

Accession:: GSE74474

ID:: 200074474

Select item 20008428320.

Identification of Sc and Esg chromatin-binding sites by ChIP-Seq analysis in progenitor cells of Drosophila midgut

(Submitter supplied) To study the antagonism between Esg and Sc, we compared their direct binding sites identified by 3HA-esg and 3HA-sc ChIP-Seq. Through ChIP-Seq analysis, 14347 binding sites of Sc and 2765 binding sites of Esg were identified through p-value cutoff 1.00e-05. Among Sc binding sites, 10675 were protein-coding genes and 2678 localized to promoter region. For Esg, 2036 were protein-coding genes and 846 localized to promoter region. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17275
4 Samples

Download data: BW, XLS

Series

Accession:: GSE84283

ID:: 200084283

PubMed Full text in PMC Similar studies SRA Run Selector

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