GEO DataSets

Analysis of kidneys from Hoxa11/Hoxd11 double null mutants at various embryonic ages up to E16.5. Hox11 genes play critical roles in kidney development. Results provide insight into the molecular mechanisms of Hox11 function in kidney development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 age, 2 genotype/variation sets

Platform:

GPL340

Series:

GSE3808

14 Samples

Download data: CEL, EXP

(Submitter supplied) E11.5 metanephric mesenchyme and ureteric bud were dissected from the E11.5 kidney rudiment using fine manual microdissection (ureteric bud only) or both fine manual microdissection and laser capture microdissection (metanephric mesenchyme) to define the gene expression profiles of these structures. Additionally, HoxA11, HoxD11 compound null E11.5 metanephric mesenchyme was obtained through laser capture microdissection allowing analysis of possible Hox targets in kidney development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2032

Platform:

GPL1261

16 Samples

Download data: CEL

(Submitter supplied) Complete (whole) embryonic kidneys were dissected from wild type and Hoxa11, Hoxd11 compound null embryons throughout development. Targets from two biological replicates of each were generated and the expression profiles were determined using Affymetrix MOE430A and MOE430B arrays. Comparisons between normal and mutant and comparisons of development samples identified global patterns of gene regulation in kidney development Keywords: embryonic metanephric kidney, kidney development, Hoxa11, Hoxd11, compound null targeted mice

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2030 GDS2031

Platforms:

GPL339 GPL340

28 Samples

Download data: CEL, EXP

Analysis of metanephric mesenchyme (MM) dissected from the rudimentary kidney of embryonic day E11.5 Hoxa11 Hoxd11 null mutants and wild types. Gene expression in wild type ureteric bud (UB) examined. Hox11 genes are expressed in the early MM and are required for the induction of UB formation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL1261

Series:

GSE3822

16 Samples

Download data: CEL

Analysis of kidneys from Hoxa11/Hoxd11 double null mutants at various embryonic ages up to E16.5. Hox11 genes play critical roles in kidney development. Results provide insight into the molecular mechanisms of Hox11 function in kidney development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 age, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE3808

14 Samples

Download data: CEL, EXP

(Submitter supplied) 10.5dpc Metanephric Mesenchyme V Intermediate Mesoderm Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

4 Samples

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(Submitter supplied) Direct comparison of dissected 10.5dpc metanephric mesenchyme Vs 13.5dpc fetal kidneys Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

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(Submitter supplied) Direct comparison of dissected pools of 11.5dpc metanephroi V 13.5dpc fetal kidneys. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

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(Submitter supplied) Direct comparison of dissected 10.5dpc metanephric mesenchyme Vs 11.5dpc metanephroi Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

Download data

(Submitter supplied) Array Design; Mouse Compugen 22K Spotted Oligo Author; Sean Grimmond Common Reference (Yes/No, ID); Yes Mouse universal Reference (Stratagene) Concentration; 100 Data processing/normalization; Lowess Normalisation GeneSpring) Developmental Stage; embryonic Diseased/Normal; normal Dye Swap; red/green Experiment Type; time course Genetic Characteristic; Wild type Image Analysis Software; Imagene5.5 (Biodiscovery) Labeling Protocol; Amino Allyl Message Amp- Ambion Organ/Organism part; kidney Organism; Mus Musculus RNA type; aRNA Message Amp-ambion Tissue Type; Pool of whole organs Organization; IMB, Uni of QLD, Brisbane Australia Sample Source; primary tissue Sampling Method; Dissection of whole organ Sex; Pool of both sexes Strain/Cell-line; CD1 Series_overall_design: To account for dye swap, the signal channel and control channel measurements for each sample were reversed. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL1873 GPL80

38 Samples

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(Submitter supplied) Triplicate pairwise comparsion of FACS sorted GFP+ve Vs GFP-ve cells from the kidneys of the HoxB7-GFP transgenic mice on compugen 22K mouse arrays. HoxB7-GFP mice express GFP in the ureteric tree and its derivatives while the metanephric mesenchyme, interstitium, developing vasculature etc do not. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

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(Submitter supplied) The Lim1 gene has essential functions during several stages of kidney development. In particular, a tissue specific knockout in the early metanephric mesenchyme results in the formation of the earliest nephron precursor, the renal vesicle, but failure of this structure to progress to the next stage, the comma shaped body. To better understand the molecular nature of this developmental arrest we used a laser capture microdissection-microarray strategy to examine the perturbed gene expression pattern of the mutant renal vesicles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2748

Platform:

GPL1261

9 Samples

Download data: CEL, CHP

Analysis of Lim1-null renal vesicles microdissected from embryonic day 12.5 kidneys. In Lim1 null embryos, the formation of comma shaped bodies from renal vesicles is interrupted. Results provide insight into the molecular basis of this developmental arrest.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE7257

9 Samples

Download data: CEL, CHP

(Submitter supplied) In this study we identify molecules with highly restricted expression patterns during the initial stages of metanephric development, when the ureteric bud has entered the metanephric mesenchyme and initiated branching morphogenesis. Using the Affymetrix Mouse Genome 430 2.0 Array, we compare gene expression patterns in ureteric bud tips, stalks and metanephric mesenchymes from mouse E12.5 embryos. To identify conserved molecular pathways, we also analyze transcriptional profiles in rat E13.5 ureteric buds and metanephric mesenchymes using the Affymetrix Rat Genome U34 Set. more...

Organism:

Rattus norvegicus; Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1572 GDS1581 GDS1582 GDS1583

4 related Platforms

18 Samples

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Analysis of ureteric bud (UB) tips and stalks and metanephric mesenchyme (MM) from E12.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 tissue sets

Platform:

GPL1261

Series:

GSE1983

6 Samples

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Analysis of ureteric buds (UBs) and metanephric mesenchyme (MM) from E13.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL87

Series:

GSE1983

4 Samples

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Analysis of ureteric buds (UBs) and metanephric mesenchyme (MM) from E13.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL86

Series:

GSE1983

4 Samples

Download data

Analysis of ureteric buds (UBs) and metanephric mesenchyme (MM) from E13.5 kidneys. UB-secreted factors induce conversion of adjacent MM cells into nephrons. Results identify as potential regulators a set of 20 secreted molecules specific to the UB and conserved between species.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL85

Series:

GSE1983

4 Samples

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(Submitter supplied) We generated a murine genetic model of beta-catenin deficiency targeted to the ureteric bud cell lineage to study the role of beta-catenin mediated Wnt signaling during ureteric morphogenesis. Keywords: mutation

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3322

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of embryonic (E12.5) kidneys with beta-catenin deficiency targeted to the ureteric bud cell lineage. Inactivation of beta-catenin leads to abnormal ureteric branching and causes renal aplasia or dysplasia. Results provide insight into the role of beta-catenin during ureteric morphogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE9629

6 Samples

Download data: CEL