2GK2,1L6Z,4JGJ


Conserved Protein Domain Family
IgV_CEACAM_D1
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cd05774: IgV_CEACAM_D1 
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First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.
Links
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Statistics
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PSSM-Id: 409430
Aligned: 28 rows
Threshold Bit Score: 124.689
Created: 24-Oct-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ###                                                                            
2GK2_A         6 LTTESmpFNVAEGKEVLLLVHNLPQQLFGYSWYKGervdgnrQIVGYAIg-tQQATPGPANSGRETIYPNASLLIQNVTQ 84  human
NP_082512     32 IFISPdsLLGVEKYRTILTLENVPEDVLEYSWYRGkdnstenMIFSYKPp--NTRHPGPSYSGRENVTRAGSLVVRMSAV 109 house mouse
Q63111       394 LTIDPvpRHAAKGESVLLQVRNLPEDLRMFIWFKSvytsqifKIAEYSRa-iNYVFRGPAHSGRETVYTNGSLLLQDATE 472 Norway rat
NP_001020575 156 MTIELsqSRVFETDHIILVGYNLPEKILGFAWHKGvlpldrfKIASHSFi-tNSSMLGSQYHQRIITCDDGSMMFLNVTQ 234 Norway rat
BAE20744     155 LKIEFvpPRIEENDDVLLLVYNLPENLQGFVWHKGvfpvdhfKIASHSFl-tNSTMLGRTYLDRLTVCSDGSLLLSKVSQ 233 house mouse
EAW57290      11 ISITLepAQPSEGDNVTLVVHGLSGELLAYSWYAGptlsvsyLVASYIVs-tGDETPGPAHTGREAVRPDGSLDIQGILP 89  human
EAW57290     308 TMIVPvpTKPTEGQDVTLTVQGYPKDLLVYAWYRGpasepnrLLSQLPS---GTWIAGPAHTGREVGFPNCSLLVQKLNL 384 human
EDM08271      36 VTIELvpPQVVEGEDVLFLVHKLPENLIGFCWYKGspi-ikhGIALYEAn-tKVGVAGPMYSARETLYRNGSMLIHNVTQ 113 Norway rat
EDM08272      63 PSIETlpPIVQDGKDVVLQVRNLPENLLGFAWFKGmtqatthLIGRYIIeenPSFSFGPASSGREKLYTDGSLLIENVTQ 142 Norway rat
AAI58512      35 IGDQLipQYPVVSQSVTLSVTGVTGTIRQFTWYKGssadtnnQIFSVIPs-aNSVTEGPQYFPRANWFPNGSLQISGLVP 113 western clawed ...

Feature 1                                       
2GK2_A        85 NDTGFYTLQVIksd-----lvnEEATGQFHV 110 human
NP_082512    110 NDTGYYTVEVDtsn------etQRATGWLQI 134 house mouse
Q63111       473 KDTGLYTLQIIyrn-----fkiETAHVQVSV 498 Norway rat
NP_001020575 235 KDSGLYTLRAIsvd-----lvtEWAIVDLKV 260 Norway rat
BAE20744     234 EDTGLYSLRTIpvd-----lmsESAIVYLKV 259 house mouse
EAW57290      90 RHSGTYILQTFnrq-----lqtEVGYGHVQV 115 human
EAW57290     385 TDTGRYTLKTVtvq-----gktETLEVELQV 410 human
EDM08271     114 KDTGFYRLRIFnrhrerrsdviRMVSEFLKR 144 Norway rat
EDM08272     143 KDAGLYTLGILgtd-----mksQEAHGEIQV 168 Norway rat
AAI58512     114 TDQGNYTVQLVtae------srAQHTVSLPV 138 western clawed frog

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